The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.

Authors:
Tessa Cutler
Tessa Cutler
University of Melbourne
Australia
Prof Sisira Siribaddana, MBBS, MD, FCCP, FRCP Edin FRCP Lon
Prof Sisira Siribaddana, MBBS, MD, FCCP, FRCP Edin FRCP Lon
Faculty of Medicine & Allied Sciences, Rajarata University of Sri Lanka
Prof
Health
Anuradhapura | Sri Lanka
Prof Richard Saffery, PhD
Prof Richard Saffery, PhD
Murdoch Childrens Research Institute
Principal Research Fellow
Epigenetics
Parkville, VIC | Australia
Karri Silventoinen Aline Jelenkovic Reijo Sund Chika Honda Sari Aaltonen Yoshie Yokoyama Adam D Tarnoki David L Tarnoki Feng Ning Fuling Ji Zengchang Pang Juan R Ordoñana Juan F Sánchez-Romera Lucia Colodro-Conde S Alexandra Burt Kelly L Klump Sarah E Medland Grant W Montgomery Christian Kandler Tom A McAdams Thalia C Eley Alice M Gregory Kimberly J Saudino Lise Dubois Michel Boivin Claire M A Haworth Robert Plomin Sevgi Y Öncel Fazil Aliev Maria A Stazi Corrado Fagnani Cristina D'Ippolito Jeffrey M Craig Sisira H Siribaddana Matthew Hotopf Athula Sumathipala Timothy Spector Massimo Mangino Genevieve Lachance Margaret Gatz David A Butler Gombojav Bayasgalan Danshiitsoodol Narandalai Duarte L Freitas José Antonio Maia K Paige Harden Elliot M Tucker-Drob Kaare Christensen Axel Skytthe Kirsten O Kyvik Changhee Hong Youngsook Chong Catherine A Derom Robert F Vlietinck Ruth J F Loos Wendy Cozen Amie E Hwang Thomas M Mack Mingguang He Xiaohu Ding Billy Chang Judy L Silberg Lindon J Eaves Hermine H Maes Tessa L Cutler John L Hopper Kelly Aujard Patrik K E Magnusson Nancy L Pedersen Anna K Dahl Aslan Yun-Mi Song Sarah Yang Kayoung Lee Laura A Baker Catherine Tuvblad Morten Bjerregaard-Andersen Henning Beck-Nielsen Morten Sodemann Kauko Heikkilä Qihua Tan Dongfeng Zhang Gary E Swan Ruth Krasnow Kerry L Jang Ariel Knafo-Noam David Mankuta Lior Abramson Paul Lichtenstein Robert F Krueger Matt McGue Shandell Pahlen Per Tynelius Glen E Duncan Dedra Buchwald Robin P Corley Brooke M Huibregtse Tracy L Nelson Keith E Whitfield Carol E Franz William S Kremen Michael J Lyons Syuichi Ooki Ingunn Brandt Thomas Sevenius Nilsen Fujio Inui Mikio Watanabe Meike Bartels Toos C E M van Beijsterveldt Jane Wardle Clare H Llewellyn Abigail Fisher Esther Rebato Nicholas G Martin Yoshinori Iwatani Kazuo Hayakawa Finn Rasmussen Joohon Sung Jennifer R Harris Gonneke Willemsen Andreas Busjahn Jack H Goldberg Dorret I Boomsma Yoon-Mi Hur Thorkild I A Sørensen Jaakko Kaprio

Twin Res Hum Genet 2015 Aug 27;18(4):348-60. Epub 2015 May 27.

Department of Public Health,University of Helsinki,Helsinki,Finland.

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

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Source
http://www.journals.cambridge.org/abstract_S1832427415000298
Publisher Site
http://dx.doi.org/10.1017/thg.2015.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696543PMC
August 2015
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15 Citations
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References

(Supplied by CrossRef)

Eveleth et al.
2003

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