IL-10-independent regulatory B-cell subsets and mechanisms of action.

Authors:
Avijit Ray, PhD
Avijit Ray, PhD
AbbVie
Senior Scientist II
Immunology, Immuno-oncology, Autoimmunity and Inflammation, Immune tolerance
North Chicago, IL | United States
Luman Wang
Luman Wang
School of Basic Medical Sciences
West Lafayette | United States
Bonnie N Dittel
Bonnie N Dittel
Blood Research Institute

Int Immunol 2015 Oct 20;27(10):531-6. Epub 2015 May 20.

BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, WI 53201, USA

Although classically B cells are known to play important roles in immune protection via humoral immunity, recently their regulatory mechanisms have been best appreciated in the context of autoimmunity. Several studies have identified different subsets of regulatory B cells that vary not only in their phenotype but also in their mechanism of action. Although the best-studied mechanism of B-cell immune regulation is IL-10 production, other IL-10-independent mechanisms have been proposed. These include maintenance of CD4(+)Foxp3(+) regulatory T cells; production of transforming growth factor-β, IL-35, IgM or adenosine or expression of PD-L1 (programmed death 1 ligand 1) or FasL (Fas ligand). Given that B-cell-targeted therapy is being increasingly used in the clinic, a complete understanding of the mechanisms whereby B cells regulate inflammation associated with specific diseases is required for designing safe and effective immunotherapies targeting B cells.

Download full-text PDF

Source
http://dx.doi.org/10.1093/intimm/dxv033DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
October 2015
11 Reads
16 Citations
2.540 Impact Factor

Publication Analysis

Top Keywords

regulatory cells
8
cells
5
regulation il-10
4
immune regulation
4
associated specific
4
il-10 production
4
production il-10-independent
4
mechanisms proposed
4
inflammation associated
4
il-10-independent mechanisms
4
b-cell immune
4
mechanism b-cell
4
vary phenotype
4
specific diseases
4
cells vary
4
pd-l1 programmed
4
phenotype mechanism
4
mechanism action
4
best-studied mechanism
4
action best-studied
4

References

(Supplied by CrossRef)
The role of IL-10 in human B cell activation, proliferation, and differentiation
Itoh et al.
J. Immunol 1995
Bidirectional effect of interleukin-10 on early murine B-cell development: stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells
Veiby et al.
Blood 1997

Similar Publications