Oncotarget 2015 Jun;6(17):15077-94
Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA.
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Cancer Res 2017 05 24;77(9):2266-2278. Epub 2017 Feb 24.
Department of Pediatrics and Aflac Cancer Center of Children's Health Care of Atlanta, Emory University School of Medicine, Atlanta, Georgia.
In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dynamics of TAM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in combination with CX3CR1;CCR2 double knock-in mice. Using this approach, we demonstrated that CX3CR1CCR2 monocytes were recruited to the GBM, where they transitioned to CX3CR1CCR2 macrophages and CX3CR1CCR2 microglia-like cells. Read More
Exp Cell Res 2010 May 23;316(9):1553-66. Epub 2010 Feb 23.
Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, Kiel, Germany.
The transmembrane chemokine CX3CL1 and its receptor CX3CR1 are thought to be involved in the trafficking of immune cells during an immune response and in the pathology of various human diseases including cancer. However, little is known about the expression and function of CX3CR1 in human glioma-infiltrating microglia/macrophages (GIMs), representing the major cellular stroma component of highly malignant gliomas. Here, we show that CX3CR1 is overexpressed at both the mRNA and protein level in solid human astrocytomas of different malignancy grades and in glioblastomas. Read More
J Neuroimmunol 2008 Jul 27;198(1-2):98-105. Epub 2008 May 27.
Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610-0267, USA.
Human glioblastoma multiforme (GBM) is the most malignant form of human brain tumors. A characteristic of GBM is the marked presence of tumor infiltrated microglia/macrophages and lymphocytes. The goal of this study was directed toward understanding the role of the chemokine system CX3CL1 and its receptor CX3CR1 in the GL261 murine model of malignant glioma. Read More
J Neuroinflammation 2017 03 21;14(1):60. Epub 2017 Mar 21.
Inserm, U 1127, F-75013, Paris, France.
Background: Evidence from mice suggests that brain infiltrating immune cells contribute to neurodegeneration, and we previously identified a deleterious lymphocyte infiltration in Parkinson's disease mice. However, this remains controversial for monocytes, due to artifact-prone techniques used to distinguish them from microglia. Our aim was to reassess this open question, by taking advantage of the recent recognition that chemokine receptors CCR2 and CX3CR1 can differentiate between inflammatory monocytes and microglia, enabling to test whether CCR2 monocytes infiltrate the brain during dopaminergic (DA) neurodegeneration and whether they contribute to neuronal death. Read More