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Gut 2022 Jun 30. Epub 2022 Jun 30.

Department of Medicine, Michael E. De Bakey VA Medical Center, Baylor College of Medicine Houston, Houston, Texas, USA.

Objective: Autoimmune gastritis (AIG) is an immunomediated disease targeting parietal cells, eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at elucidating the natural history, histological phenotype(s), and associated cancer risk of patients with AIG consistently tested -negative (naïve -negative subjects).

Design: Two-hundred eleven naïve -negative patients (tested by serology, histology, molecular biology) with AIG (F:M=3. Read More

JCO Precis Oncol 2022 Jun;6:e2100289

Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Purpose: Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker for baseline characterization and longitudinal monitoring of a tumor throughout disease management. The aim of this study was to evaluate the utility of ctDNA across a wide spectrum of tumor types.

Methods: We retrospectively identified 1,763 patients with advanced cancers who had next-generation sequencing of ctDNA or tumor tissue completed by a designated commercial assay at Northwestern University. Read More

Int J Clin Oncol 2022 Jun 30. Epub 2022 Jun 30.

Department of Surgery, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.

Background: The frailty was associated with the worse surgical outcomes and poor prognosis in several cancers. Therefore, we aimed to identify the usefulness of nutrition and exercise intervention (NEI) in frailty patients with GC.

Methods: We analyzed 58 frailty patients with GC who underwent radical surgery. Read More

Cancer Epidemiol Biomarkers Prev 2022 Jun 30. Epub 2022 Jun 30.

Stanford University School of Medicine, Stanford, CA, United States.

Background: Gastric cancer (GC) is a leading cause of cancer morbidity and mortality. Developing information systems which integrate clinical and genomic data may accelerate discoveries to improve cancer prevention, detection, and treatment. To support translational research in GC, we developed the GC Registry (GCR), a North American repository of clinical and cancer genomics data. Read More

Aging (Albany NY) 2022 Jun 27;14(undefined). Epub 2022 Jun 27.

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Matrine has been shown to play a role in the suppression of gastric cancer (GC) tumorigenesis. However, whether long non-coding RNA NUT family member 2A-antisense RNA 1 (NUTM2A-AS1) is involved in matrine-induced inhibition of GC remains unknown. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, cell colony formation, and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays were employed to determine the proliferation, viability, and apoptosis of GC cells, respectively. Read More