Thyroid hormones and prolactin levels in infertile women in southern Nigeria.

Authors:
Dr. Iya Eze Bassey, PhD
Dr. Iya Eze Bassey, PhD
University of Calabar
Chemical Pathology
Calabar, CrossRiver | Nigeria
Alphonsus Ekpe Udoh
Alphonsus Ekpe Udoh
University of Calabar /Consultant Chemical Pathologist
Okon Ekwerre Essien
Okon Ekwerre Essien
University of Calabar/Consultant Physician
Idongesit Kokoabasi Paul Isong
Idongesit Kokoabasi Paul Isong
University of Calabar. Nigeria
Dr
Calabar, Cross River State | Nigeria
Rebecca Mtaku Gali
Rebecca Mtaku Gali
University of Maiduguri
Nigeria
Edim Eyo Archibong
Edim Eyo Archibong
Principal Medical Laboratory Scientist

J Clin Diagn Res 2015 Mar 1;9(3):OC13-5. Epub 2015 Mar 1.

Principal Medical Laboratory Scientist, Department of Chemical Pathology, University of Calabar Teaching Hospital , Calabar, Nigeria .

Introduction: Human infertility is a complex global health problem. It has multiple social consequences which are especially profound for thyroid hormones in infertility with the aim of determining the degree of association of thyroid hormones with hyperprolactinemia in our population.

Materials And Methods: The serum levels of prolactin, T3, T4 and TSH were determined in 90 hyperprolactinemic infertile women, 90 normoprolactinemic infertile women and 50 fertile women. The hormones were assayed using Enzyme Linked Immunosorbent Assay kits.

Statistical Analysis: Analysis of variance and Pearson's correlation were used to analyze the data, with the significant p-level set at 0.05.

Results: A significantly higher mean serum prolactin and TSH were observed among the infertile groups compared to the fertile controls (p<0.05). The mean serum T3 and T4 were significantly lower in the hyperprolactinemic infertile women compared to the fertile controls (p<0.05). The mean TSH and T3 of normoprolactinemic infertile women and controls were comparable (p>0.05). However, the mean T4 was significantly lower in normoprolactinemic infertile women compared to the fertile controls (p<0.05). In all the groups, TSH correlated inversely with T3 and T4, while T3 correlated positively with T4. It was only in the control group that prolactin correlated positively and significantly with TSH.

Conclusion: It is therefore concluded that hyperprolactinemia with thyroid dysfunction may be a major contributory hormonal factor in infertility among infertile women and as such, estimation of prolactin, T3, T4 and TSH should be included in the workup for infertile women especially those with hyperprolactinaemia.

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Source
http://dx.doi.org/10.7860/JCDR/2015/11505.5659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413097PMC

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March 2015
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