Management of venous thromboembolism in patients with acute leukemia at high bleeding risk: a multi-center study.

Leuk Lymphoma 2016 25;57(1):116-9. Epub 2015 May 25.

a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.

In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. The authors performed a multi-center study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. The intention was to find as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.

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http://dx.doi.org/10.3109/10428194.2015.1046864DOI Listing
October 2016

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