J Cutan Pathol 2015 Oct 21;42(10):722-9. Epub 2015 May 21.
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
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J Cutan Pathol 2010 Apr;37(4):416-25
Department of Pathology, University of California, San Francisco, San Francisco, CA 94115, USA.
Background: The clinical differential diagnosis of photo-distributed papules and plaques includes polymorphous light eruption (PMLE) and lupus erythematosus (LE). These entities share many histopathological features. However, in most contemporary textbooks, a broad band of papillary dermal edema is reported to be characteristic of PMLE and not seen in LE. Read More
Exp Dermatol 2005 Feb;14(2):138-42
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Background: The pathogenic mechanisms of UV-induced skin lesions of lupus erythematosus (LE) are unknown. In a recent study of pathogenic mechanisms of polymorphic light eruption (PLE), significantly more Langerhans cells (LCs) persisted in the epidermis after UVB overexposure than in healthy individuals. Interestingly, the same phenomenon was observed in one subacute cutaneous lupus erythematosus (SCLE) patient. Read More
J Am Acad Dermatol 2003 Jun;48(6):901-8
Departments of Dermatology at Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.
Background: In a recent study, we demonstrated that lupus erythematosus (LE) tumidus (LET) is a distinct subset of cutaneous LE (CLE), which is clinically characterized by erythematous, urticaria-like, nonscarring plaques in sun-exposed areas.
Objective: Our purpose was to analyze skin biopsy specimens from 80 patients with this disease and to determine whether it could be differentiated from other variants of CLE on histopathologic grounds.
Methods: Skin biopsy specimens from 53 primary and 38 UVA- and/or UVB-induced lesions of 80 patients with LET were examined and compared with skin biopsy specimens from patients with discoid LE (DLE) and subacute CLE (SCLE). Read More
J Cutan Pathol 2008 Aug 14;35(8):757-60. Epub 2008 Jan 14.
Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.
Alopecia areata is an autoimmune disease causing patchy hair loss, which occurs with an increased incidence in patients with lupus erythematosus. We report a 27-year-old African-American female with systemic lupus erythematosus and alopecia areata, whose biopsy showed a marked increase in mucin in the deep dermis and subcutis. Archival biopsies of alopecia areata were then reviewed to see if this finding occurs in patients without systemic lupus. Read More