Pharmacogenomic assessment of Mexican and Peruvian populations.

Authors:
Sharon Marsh
Sharon Marsh
Washington University School of Medicine
United States
Cristi R King
Cristi R King
Washington University School of Medicine
United States
Jane Y Revollo
Jane Y Revollo
Campbell University College of Pharmacy and Health Sciences
United States
Robert H Gilman
Robert H Gilman
Johns Hopkins Bloomberg School of Public Health
Baltimore | United States
Howard L McLeod
Howard L McLeod
University of North Carolina
United States

Pharmacogenomics 2015 ;16(5):441-8

Faculty of Pharmacy & Pharmaceutical Sciences, 3142F Katz Centre for Pharmacy & Health Research, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Background: Clinically relevant polymorphisms often demonstrate population-specific allele frequencies. Central and South America remain largely uncategorized in the context of pharmacogenomics.

Materials & Methods: We assessed 15 polymorphisms from 12 genes (ABCB1 3435C>T, ABCG2 Q141K, CYP1B1*3, CYP2C19*2, CYP3A4*1B, CYP3A5*3C, ERCC1 N118N, ERCC2 K751Q, GSTP1 I105V, TPMT 238G>C, TPMT 460G>A, TPMT 719A>G, TYMS TSER, UGT1A1*28 and UGT1A1 -3156G>A) in 81 Peruvian and 95 Mexican individuals.

Results: Six polymorphism frequencies differed significantly between the two populations: ABCB1 3435C>T, CYP1B1*3, GSTP1 I105V, TPMT 460G>A, UGT1A1*28 and UGT1A1 -3156G>A. The pattern of observed allele frequencies for all polymorphisms could not be accurately estimated from any single previously studied population.

Conclusion: This highlights the need to expand the scope of geographic data for use in pharmacogenomics studies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515450PMCFound
January 2016
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