Pharmacogenomics 2015 ;16(5):441-8
Faculty of Pharmacy & Pharmaceutical Sciences, 3142F Katz Centre for Pharmacy & Health Research, University of Alberta, Edmonton, AB T6G 2E1, Canada.
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Mol Biol Rep 2012 May 9;39(5):6343-51. Epub 2012 Feb 9.
ICMR Centre for Advance Research in Pharmacogenomics, Department of Pharmacology, JIPMER, Pondicherry, India.
Molecular variants of polymorphic drug metabolizing enzymes and drug transporters are attributed to differences in individual's therapeutic response and drug toxicity in different populations. We sought to determine the genotype and allele frequencies of polymorphisms for major phase II drug-metabolizing enzymes (TPMT, UGT1A1) and drug transporter (MDR1) in South Indians. Allelic variants of TPMT (*2,*3A,*3B,*3C & *8), UGT1A1 (TA)6>7 and MDR1 (2677G>T/A & 3435C>T) were evaluated in 450-608 healthy South Indian subjects. Read More
Clin Chim Acta 2008 Dec 23;398(1-2):82-5. Epub 2008 Aug 23.
Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, 633-165 Gaegum-dong, Jin-gu, Busan 614-735, Republic of Korea.
Background: Thiopurine S-methyltransferase (TPMT) genetic polymorphisms have been studied intensively in relation to thiopurine toxicity. In the present study, an improved pyrosequencing method was developed for TPMT genotyping and used to investigate the genotype frequency in Korean and Vietnamese populations.
Methods: Four-hundred Korean and 159 Vietnamese subjects were genotyped by pyrosequencing for TPMT 238G>C, 460G>A, 539A>T, and 719A>G variants, in order to determine the TPMT*2, *3A, *3B, *3C, and *6 alleles. Read More
Pharmacogenomics 2007 Jul;8(7):703-12
University of Porto, Institute of Pathology and Molecular Immunology, 4200-465 Porto, Portugal.
Objective: Most drugs are developed based on data from European-derived 'reference' populations; however, clinically relevant DNA polymorphisms often demonstrate population-specific patterns of allele frequencies. Given that the knowledge of the frequency distribution of functional polymorphisms in a population may guide national planning for selection of therapeutic options, in the present study we examined the allele frequencies of enzymes responsible for drug disposition in Portugal.
Patients & Methods: Using PCR- and Pyrosequencing-based methods, the current study assessed the frequencies of 15 key polymorphisms from genes encoding enzymes involved in Phases I, II and III of drug metabolism, DNA repair and intracellular metabolism in 135 healthy individuals from Portugal. Read More
Clin Res Hepatol Gastroenterol 2012 Apr 4;36(2):178-84. Epub 2012 Jan 4.
Service de pharmacologie clinique, Centre national de pharmacovigilance, Tunis, Tunisia.
Aim: The aim of this study was to determine the frequencies of TPMT and ITPA polymorphisms in Crohn's disease patients of Tunisian origin and to compare them with allele frequencies previously reported in other populations of various ethnic origins.
Methods: ITPA (c.94C>A and IVS2+21A>C) and TPMT (c. Read More