Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

Cell Cycle 2015 ;14(12):1842-58

a College of Veterinary Medicine; South China Agricultural University ; Guangzhou , China.

Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploidization of decidual cells. E2F8-mediated polyploidization is a response to stresses which are accompanied by decidualization. Interestingly, polyploidization is not detected during human decidualization with the down-regulation of E2F8, indicating differential expression of E2F8 may lead to the difference of decidual cell polyploidization between mice and humans.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2015.1
Publisher Site
http://dx.doi.org/10.1080/15384101.2015.1033593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614110PMC
April 2016
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