Anal Chim Acta 2015 May 26;872:95-9. Epub 2014 Dec 26.
Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Glasnevin, Dublin 9, Ireland; School of Physical Sciences, National Centre for Sensor Research, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:
Download full-text PDF
Lab Chip 2012 Dec;12(23):5007-15
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Methods that allow monitoring of individual cells over time, using live cell imaging, are essential for studying dynamical cellular processes in heterogeneous cell populations such as primary T lymphocytes. However, applying single cell time-lapse microscopy to study activation and differentiation of these cells was limited due to a number of reasons. First, primary naïve T cells are non-adherent and become highly motile upon activation through their antigen receptor. Read More
Lab Chip 2013 Mar 18;13(5):947-54. Epub 2013 Jan 18.
Department of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
We designed a microfluidic chemostat consisting of 600 sub-micron trapping/growth channels connected to two feeding channels. The microchemostat traps E. coli cells and forces them to grow in lines for over 50 generations. Read More
Anal Chem 2009 May;81(9):3261-9
Sandia National Laboratories, 7011 East Avenue, Livermore, California 94550, USA.
The ability to monitor cell signaling events is crucial to the understanding of immune defense against invading pathogens. Conventional analytical techniques such as flow cytometry, microscopy, and Western blot are powerful tools for signaling studies. Nevertheless, each approach is currently stand-alone and limited by multiple time-consuming and labor-intensive steps. Read More
J Immunol 2007 Nov;179(9):6052-63
Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia.
C-type lectin receptors play important roles in mononuclear phagocytes, which link innate and adaptive immunity. In this study we describe characterization of the novel type I transmembrane C-type lectin DCL-1/CD302 at the molecular and cellular levels. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. Read More