Anti-Basal Ganglia Antibodies and Streptococcal Infection in ADHD.

J Atten Disord 2018 07 16;22(9):864-871. Epub 2015 Apr 16.

2 Clínica Universidad de Navarra, Pamplona, Spain.

Objective: Group A Streptococcus has been associated with ADHD, tic disorders (TD), and obsessive-compulsive disorder (OCD) through anti-basal ganglia antibodies (ABGA).

Method: We investigated the association between ABGA and streptococcal exposure with behavioral, motor, and cognitive measures in 38 children with ADHD not comorbid to OCD or TD (nc-ADHD) and in 38 healthy children. An additional group of 15 children with TD and/or OCD was examined.

Results: ABGA titers were present in 3% of nc-ADHD patients and controls but in 27% of TD and/or OCD patients. Evidence of streptococcal exposure was similar between ADHD patients and controls living in the same urban area. Behavioral, motor, and cognitive measures were not associated with anti-streptococcal antibodies.

Conclusion: ABGA do not distinguish nc-ADHD from controls. The differences in the frequency of streptococcal exposure in previous studies are determined by the dynamic nature of the infection rather than the behavioral phenotype of ADHD.

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Source
http://journals.sagepub.com/doi/10.1177/1087054715580841
Publisher Site
http://dx.doi.org/10.1177/1087054715580841DOI Listing
July 2018
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