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Bioresour Technol 2021 Mar 2;329:124926. Epub 2021 Mar 2.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address:

Cellulosic ethanol fermentability of ethanologenic strain Zymomonas mobilis is severely inhibited by phenolic aldehydes generated from lignocellulose pretreatment. Here, a 198 days' laboratory adaptive evolution of Z. mobilis 8b in corn stover hydrolysate was conducted to increase its phenolic aldehydes tolerance and ethanol fermentability. Read More

Mol Plant 2021 Mar 5. Epub 2021 Mar 5.

ARC Centre of Excellence for Plant Success in Nature and Agriculture.

J Theor Biol 2021 Mar 5:110660. Epub 2021 Mar 5.

Program in Bioinformatics and Computational Biology, University of Idaho, Moscow, Idaho 83844; Department of Mathematics, University of Idaho, 875 Perimeter Drive MS 1103, Moscow, Idaho, 83844.

Although the evolutionary response to random genetic drift is classically modelled as a sampling process for populations with fixed abundance, the abundances of populations in the wild fluctuate over time. Furthermore, since wild populations exhibit demographic stochasticity and since random genetic drift is in part due to demographic stochasticity, theoretical approaches are needed to understand the role of demographic stochasticity in eco-evolutionary dynamics. Here we close this gap for quantitative characters evolving in continuously reproducing populations by providing a framework to track the stochastic dynamics of abundance density across phenotypic space using stochastic partial differential equations. Read More

J Theor Biol 2021 Mar 5:110661. Epub 2021 Mar 5.

Department of Biological Sciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 25250, USA.

A series of prior publications has reported unusual properties of the set of genetically encoded amino acids shared by all known life. This work uses quantitative measures (descriptors) of size, charge and hydrophobicity to compare the distribution of the genetically encoded amino acids with random samples of plausible alternatives. Results show that the standard "alphabet" of amino acids established by the time of LUCA is distributed with unusual evenness over a broad range for the three, key physicochemical properties. Read More

ACS Synth Biol 2021 Mar 8. Epub 2021 Mar 8.

Department of Plant and Microbial Biology, University of California, Berkeley, California 94720-3102, United States.

The living cell possesses extraordinary molecular and biochemical mechanisms by which to recognize and efficiently remove foreign, damaged, or denatured proteins. This essential function has been a barrier to the overexpression of recombinant proteins in most expression systems. A notable exception is the overexpression in of recombinant proteins, most of which, however, end-up as "inclusion bodies", , cytoplasmic aggregates of proteins that are inaccessible to the cell's proteasome. Read More