The Effect of Hydro-Alcoholic Extract of Foeniculum vulgare Mill on Leukocytes and Hematological Tests in Male Rats.

Jundishapur J Nat Pharm Prod 2015 Feb 20;10(1):e18396. Epub 2015 Feb 20.

Department of Laboratory Sciences, Student Research Committee, School of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.

Background: Medicinal plants have a long history in treating blood disorders, which is one of the most common problems in today's advanced world. Fennel (Foeniculum vulgare) is a medicinal plant with a high content of polyphenols and has antioxidant and immunomodulatory properties.

Objectives: The aim of this study was to evaluate the effect of hydro-alcoholic extract of fennel on some hematological indices in male rats.

Materials And Methods: In this experimental study, thirty male Wistar rats were divided into six groups (five rats in each group). The first group (control) did not receive any dose; the second group (sham) received 1 mL normal saline (extraction solvent); and the experimental groups 1, 2, 3 and 4 respectively received 1 mL hydro alcoholic extract of fennel in four doses of 250, 500, 750 and 1000 mg/kg of body weight every 48 hours for 30 days by gavage. One day after the last gavage following induction of anesthesia and taking blood from the heart of rats, measurement of red and white blood cells, hemoglobin, hematocrit and tests of bleeding and coagulation time (CT) were performed. The data was analyzed by one-way ANOVA test using SPSS15 software.

Results: Fennel increased mean RBC (7.54 ± 0.53 × 106) and WBC (5.89 ± 0.78 × 103) values, especially at a dose of 250 mg/mL and CT (2.45 ± 0.20) at a dose of 500mg/mL compared to the control group (P < 0.05).

Conclusions: Fennel increased red and white blood cells probably due to the presence of polyphenols and antioxidant activity of fennel and reduced negative effects of free radicals on blood cells.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379888PMC
http://dx.doi.org/10.17795/jjnpp-18396DOI Listing
February 2015
4 Reads

Publication Analysis

Top Keywords

blood cells
12
polyphenols antioxidant
8
red white
8
fennel increased
8
foeniculum vulgare
8
white blood
8
hydro-alcoholic extract
8
extract fennel
8
fennel
6
blood
5
gavage induction
4
induction anesthesia
4
day gavage
4
gavage day
4
hours days
4
days gavage
4
rats measurement
4
cells hemoglobin
4
hemoglobin hematocrit
4
hematocrit tests
4

Similar Publications