Antimicrob Agents Chemother 2015 16;59(6):3149-55. Epub 2015 Mar 16.
Division of Infectious Diseases Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA Departments of Epidemiology and Global Health, Emory Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
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Antimicrob Agents Chemother 2014 18;58(2):782-8. Epub 2013 Nov 18.
Kibong'oto National Tuberculosis Hospital, Kilimanjaro, Tanzania.
Little is known about plasma drug concentrations relative to quantitative susceptibility in patients with multidrug-resistant tuberculosis (MDR-TB). We previously described a TB drug activity (TDA) assay that determines the ratio of the time to detection of plasma-cocultured Mycobacterium tuberculosis versus control growth in a Bactec MGIT system. Here, we assess the activity of individual drugs in a typical MDR-TB regimen using the TDA assay. Read More
Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.
National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled. Serial serum samples were collected, and microdialysis was performed using lung tissue to measure pyrazinamide concentrations. Read More
Antimicrob Agents Chemother 2014 May 18;58(5):2948-51. Epub 2014 Feb 18.
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Limited data on fluoroquinolone pharmacokinetics and cardiac effects in children exist. Among 22 children receiving drug-resistant tuberculosis prophylaxis or treatment, serum concentrations following oral doses of levofloxacin (15 mg/kg of body weight) and ofloxacin (20 mg/kg) were lower than those expected from existing pediatric data, possibly due to differences in the formulations (crushed tablets). Drug exposures were lower than those in adults following standard doses and below the proposed pharmacodynamic targets, likely due to more rapid elimination in children. Read More
PLoS One 2017 31;12(1):e0170663. Epub 2017 Jan 31.
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, United States of America.
Therapeutic drug monitoring may improve multidrug-resistant tuberculosis (MDR-TB) treatment outcomes. Levofloxacin demonstrates significant individual pharmacokinetic variability. Thus, we sought to develop and validate a high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection for levofloxacin in patients on MDR-TB treatment. Read More