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Kidney Med 2019 Mar-Apr;1(2):65-70. Epub 2019 Mar 14.

Renal Consultants of Houston, Houston, TX.

Use of desmopressin (1-deamino-8-d-arginine vasopressin; DDAVP), a synthetic vasopressin receptor agonist, has expanded in recent years. Desmopressin leads to renal water retention, and iatrogenic hyponatremia may result if fluid intake is not appropriately restricted. It is common practice to stop a medication that is causing toxicity, and this advice is promulgated in Micromedex, which suggests withholding desmopressin if hyponatremia occurs. Read More

Acta Neurol Belg 2015 Dec 17;115(4):819-21. Epub 2015 Mar 17.

Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Jalal-e-Al-e-Ahmad Hwy, Tehran, Islamic Republic of Iran.

J Emerg Med 2006 Jan;30(1):45-7

Department of Emergency Medicine, Keck/USC School of Medicine, Los Angeles, California 90033, USA.

Nasal desmopressin (DDAVP) is a commonly prescribed antidiuretic hormone (ADH) analogue used for treatment of diabetes insipidus, polyuria and nocturnal enuresis. Although it is generally well tolerated, it can cause severe electrolyte imbalance. Numerous reports exist on cases of mild to moderate DDAVP-induced hyponatremia, yet few reports describe severe hyponatremia (Na<115 mEq/L). Read More