BMC Biophys 2014 26;7:13. Epub 2014 Nov 26.
Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD USA.
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Front Immunol 2018 29;9:75. Epub 2018 Jan 29.
Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important role in the toll-like receptor (TLR) 2, TLR4, TLR7, and TLR9 signaling pathways. TIRAP anchors to phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) on the plasma membrane and PI (3,4,5)-trisphosphate (PIP3) on the endosomal membrane and assists in recruitment of the myeloid differentiation primary response 88 protein to activated TLRs. To date, the structure and mechanism of TIRAP's membrane association are only partially understood. Read More
Biopolymers 2003 ;71(1):49-70
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV1006, Latvia.
Gelsolin is an actin-severing protein whose action is initiated by Ca(2+) and inhibited by binding to phosphorylated inositol lipid or phosphoinositides. The regions of gelsolin responsible for phosphoinositide binding are comprised of residues 150-169 (G150-169) and 135-142 (G135-142). The corresponding peptides possess similar binding potency as native gelsolin. Read More
Biochim Biophys Acta 1997 Oct;1358(3):261-78
Department of Medicine, Cooper Hospital / University Medical Center, UMDNJ / Robert Wood Johnson Medical School, Camden, NJ, USA.
Cell locomotion requires rapid growth of cortical actin filaments whose barbed ends are capped in the resting cell. Phosphatidylinositol-4,5-bisphosphate (PIP2) may play a critical role as an intracellular messenger in cytoskeletal rearrangement after stimulation. We have examined the effects of PIP2 micelles on the Ca2+-independent actin filament capping activity in high speed supernatants of neutrophil lysates which we had previously demonstrated to be almost entirely due to capping protein-beta2, a homologue of cap Z. Read More
Biochim Biophys Acta 2015 Jul 30;1848(7):1481-9. Epub 2015 Mar 30.
Institute of Experimental Botany, Academy of Sciences of the Czech Republic, 165 02 Prague, Czech Republic. Electronic address:
The exocytosis is a process of fusion of secretory vesicles with plasma membrane, which plays a prominent role in many crucial cellular processes, e.g. secretion of neurotransmitters, cytokinesis or yeast budding. Read More