Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China.

Authors:
Maohong Hu
Maohong Hu
Shandong University
China
Xiaodan Li
Xiaodan Li
National Institute for Viral Disease Control and Prevention
China
Xiansheng Ni
Xiansheng Ni
Nanchang Center for Disease Control and Prevention
Jingwen Wu
Jingwen Wu
University of Nevada School of Medicine
Rongbao Gao
Rongbao Gao
National Institute for Viral Disease Control and Prevention
China
Wen Xia
Wen Xia
Shandong University
China
Dayan Wang
Dayan Wang
National Institute for Viral Disease Control and Prevention
China
Fenglan He
Fenglan He
Nanchang Center for Disease Control and Prevention

Jpn J Infect Dis 2015 13;68(5):364-9. Epub 2015 Mar 13.

Nanchang Center for Disease Control and Prevention.

Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the city. A total of 201 specimens tested positive for AIVs among 618 samples collected from 24 LPMs in Nanchang from December 2013 to January 2014. We found that the LPMs were heavily contaminated by AIVs, with H9, H10, and H5 being the predominant subtypes and more than half of the LPMs providing samples that were positive for the H10 subtype. Moreover, the coexistence of different subtypes was common in LPMs. Of the 201 positive samples, 20.9% (42/201) had mixed infections with AIVs of different HA subtypes. Of the 42 mixed infections, 50% (21/42) showed the coexistence of the H9 and H10 subtypes, with or without H5, and were from chicken samples. This indicated that the H10N8 virus probably originated from segment reassortment of the H9 and H10 subtypes.

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http://dx.doi.org/10.7883/yoken.JJID.2014.377DOI Listing

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June 2016
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