Nazarov cyclization of divinyl and arylvinyl epoxides: application in the synthesis of resveratrol-based natural products.

Authors:
Dr Kovela Satish, PhD
Dr Kovela Satish, PhD
Indian Institute of Chemical Technology, Hyderabad
Synthetic and medicinal chemistry
Hyderabad, Telangana | India

Chemistry 2015 Apr 11;21(17):6475-80. Epub 2015 Mar 11.

Division of CPC (Organic Chemistry-II), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007 (India).

New variation in the Nazarov cyclization has been developed by preparing divinyl and arylvinyl epoxides as pentadienyl cation precursors for the first time. Highly substituted cyclopentadienes, hydrindienes, and indenes were synthesized to demonstrate the compatibility of this reaction with substrates bearing a variety of substitutions and having different types of epoxides. Application of this method in the synthesis of resveratrol-based natural products was also demonstrated.

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http://doi.wiley.com/10.1002/chem.201500362
Publisher Site
http://dx.doi.org/10.1002/chem.201500362DOI Listing
April 2015
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1 Citation
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