Cell Cycle 2015 ;14(8):1133
a Department of Genetics, Cell Biology and Development ; University of Minnesota ; Minneapolis , MN USA.
Front Immunol 2021 25;12:633762. Epub 2021 Mar 25.
Department of Medical Laboratory Sciences, Hunter College of the City University of New York, New York, NY, United States.
Though viruses have their own genomes, many depend on the nuclear environment of their hosts for replication and survival. A substantial body of work has therefore been devoted to understanding how viral and eukaryotic genomes interact. Recent advances in chromosome conformation capture technologies have provided unprecedented opportunities to visualize how mammalian genomes are organized and, by extension, how packaging of nuclear DNA impacts cellular processes. Read More
New Phytol 2020 12 9;228(6):1852-1863. Epub 2020 Aug 9.
Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Betty-Heimann-Straße 3, Halle (Saale), 06120, Germany.
Meiotic recombination rates vary considerably between species, populations and individuals. The genetic exchange between homologous chromosomes plays a major role in evolution by breaking linkage between advantageous and deleterious alleles in the case of introgressions. Identifying recombination rate modifiers is thus of both fundamental and practical interest to understand and utilize variation in meiotic recombination rates. Read More
Proc Natl Acad Sci U S A 2020 06 4;117(24):13647-13658. Epub 2020 Jun 4.
Department of Plant Sciences, University of Cambridge, CB2 3EA Cambridge, United Kingdom
During meiosis, interhomolog recombination produces crossovers and noncrossovers to create genetic diversity. Meiotic recombination frequency varies at multiple scales, with high subtelomeric recombination and suppressed centromeric recombination typical in many eukaryotes. During recombination, sister chromatids are tethered as loops to a polymerized chromosome axis, which, in plants, includes the ASY1 HORMA domain protein and REC8-cohesin complexes. Read More
Genes (Basel) 2019 12 10;10(12). Epub 2019 Dec 10.
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA.
Both the pericentromere and the nucleolus have unique characteristics that distinguish them amongst the rest of genome. Looping of pericentromeric DNA, due to structural maintenance of chromosome (SMC) proteins condensin and cohesin, drives its ability to maintain tension during metaphase. Similar loops are formed via condensin and cohesin in nucleolar ribosomal DNA (rDNA). Read More
Science 2019 12 28;366(6471):1345-1349. Epub 2019 Nov 28.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cohesin is a chromosome-bound, multisubunit adenosine triphosphatase complex. After loading onto chromosomes, it generates loops to regulate chromosome functions. It has been suggested that cohesin organizes the genome through loop extrusion, but direct evidence is lacking. Read More