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The influence of lung ischemia-reperfusion injury on myocardium.

Authors:
Meng Shi Jiechun Huang Liewen Pang Xiaotian Sun Xianglin Chu Rongrong Jang Xiaolin Xu Yiqing Wang

Int J Clin Exp Med 2014 15;7(12):4780-6. Epub 2014 Dec 15.

Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.

Object: To investigate the effect of lung Ischemia-reperfusion injury on cardiac muscle.

Methods: SD rats were randomly divided into the following four groups: sham operation group (TS group); experimental control group (TG group); curcumin group (TC group); dexamethasone group (TM group). After 4 h and 24 h of lung ischemia-reperfusion, the cardiac muscle was collected. We measured the concentrations of TNF-α, IL-6, caspase-3, antioxidant capacity and neutrophil infiltration in myocardial tissue.

Results: After lung ischemia-reperfusion 4 h, TNF-α, IL-6 levels, MDA and neutriphils infiltration increased in myocardial tissue in control group, total antioxidant capacity decreased, and caspase-3 exhibited no significant changes. However, 24 h after reperfusion, there were no significant difference between the sham group and experimental group.

Conclusion: Lung ischemia-reperfusion injury affected the function of cardiac muscle, especially 4 h after reperfusion. Curcumin and dexamethasone effectively protected myocardial injury after lung ischemia-reperfusion.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307421PMC
February 2015

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Crosstalk between non-classical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment.

Authors:
Chitaru Kurihara Emilia Lecuona Qiang Wu Wenbin Yang Felix L Nunez-Santana Mahzad Akbarpour Xianpeng Liu Ziyou Ren Wenjun Li Melissa Querrey Sowmya Ravi Megan L Anderson Emily Cerier Haiying Sun Megan E Kelly Hiam Abdala-Valencia Ali Shilatifard Thalachallour Mohanakumar G R Scott Budinger Daniel Kreisel Ankit Bharat

JCI Insight 2021 Feb 23. Epub 2021 Feb 23.

Division of Thoracic Surgery, Northwestern University, Chicago, United States of America.

Primary Graft Dysfunction (PGD) is the predominant cause of early graft loss following lung transplantation. We recently demonstrated that donor pulmonary intravascular non-classical monocytes (NCM) initiate neutrophil recruitment. Simultaneously, host-origin classical monocytes (CM) permeabilize the vascular endothelium to allow neutrophil extravasation necessary for PGD. Read More

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February 2021
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Commentary: To die or not to die-rescuing lung cells from ischemia-reperfusion injury.

Authors:
Aadil Ali Marcelo Cypel

J Thorac Cardiovasc Surg 2021 Jan 30. Epub 2021 Jan 30.

Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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January 2021
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Protective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis.

Authors:
Satoshi Ueda Toyofumi F Chen-Yoshikawa Satona Tanaka Yoshito Yamada Daisuke Nakajima Akihiro Ohsumi Hiroshi Date

J Thorac Cardiovasc Surg 2021 Jan 22. Epub 2021 Jan 22.

Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:

Background: Necroptosis plays an important role in cell death during pulmonary ischemia-reperfusion injury (IRI). We hypothesized that therapy with necrosulfonamide (NSA), a mixed-lineage kinase domain-like protein inhibitor, would attenuate lung IRI.

Methods: Rats were assigned at random into the sham operation group (n = 6), vehicle group (n = 8), or NSA group (n = 8). Read More

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January 2021
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Bone marrow-derived mesenchymal stem cells modulate autophagy in RAW264.7 macrophages via the phosphoinositide 3-kinase/protein kinase B/heme oxygenase-1 signaling pathway under oxygen-glucose deprivation/restoration conditions.

Authors:
Ning-Fang Wang Chun-Xue Bai

Chin Med J (Engl) 2021 Feb 17. Epub 2021 Feb 17.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Background: Autophagy of alveolar macrophages is a crucial process in ischemia/reperfusion injury-induced acute lung injury (ALI). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent cells with the potential for repairing injured sites and regulating autophagy. This study was to investigate the influence of BM-MSCs on autophagy of macrophages in the oxygen-glucose deprivation/restoration (OGD/R) microenvironment and to explore the potential mechanism. Read More

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February 2021
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Effects of melatonin on protecting against lung injury (Review).

Authors:
Weiwei Wang Ju Gao

Exp Ther Med 2021 Mar 20;21(3):228. Epub 2021 Jan 20.

Department of Anesthesiology, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.

Melatonin (MT; N-acetyl-5-methoxy-tryptamine), which has multiple effects and roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to circadian regulation, MT has anti-inflammatory, antioxidant and anticancer functions. Recent studies postulated that MT serves a critical role in apoptosis, anti-ischemic reperfusion injury and anti-proliferative effects on various cells. Read More

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March 2021
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