Ascorbic Acid may Exacerbate Aspirin-Induced Increase in Intestinal Permeability.

Authors:
Professor Marlena C Kruger, PhD
Professor Marlena C Kruger, PhD
Massey University
College of Health
Bone and joint health and nutrition
Palmerston North | New Zealand
Ivana R Sequeira
Ivana R Sequeira
University of Auckland
Dr
Gastrophysiology
Auckland | New Zealand

Basic Clin Pharmacol Toxicol 2015 Sep 4;117(3):195-203. Epub 2015 Mar 4.

Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.

Ascorbic acid in combination with aspirin has been used to prevent aspirin-induced oxidative GI damage. We aimed to determine whether ascorbic acid reduces or prevents aspirin-induced changes in intestinal permeability over a 6-hr period using saccharidic probes mannitol and lactulose. The effects of administration of 600 mg aspirin alone, 500 mg ascorbic acid alone and simultaneous dosage of both agents were compared in a cross-over study in 28 healthy female volunteers. These effects were also compared with that of a placebo. The ability of ascorbic acid to mitigate the effects of aspirin when administered either half an hour before or after dosage with aspirin was also assessed in 19 healthy female volunteers. The excretion of lactulose over the 6-hr period was augmented after consumption of either aspirin or ascorbic acid compared with that after consumption of placebo. Dosage with ascorbic acid alone augmented the excretion of lactulose more than did aspirin alone. Simultaneous dosage with both agents augmented the excretion of lactulose in an additive manner. The timing of dosage with ascorbic acid in relation to that with aspirin had no significant effect on the excretion of the two sugars. These findings indicate that ascorbic acid does not prevent aspirin-induced increase in gut permeability rather that both agents augment it to a similar extent. The additive effect on simultaneous dosage with both agents in augmenting the absorption of lactulose suggests that each influences paracellular permeability by different pathways.

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcpt.12388DOI Listing
September 2015
7 Reads
1 Citation
2.380 Impact Factor

Publication Analysis

Top Keywords

ascorbic acid
36
simultaneous dosage
12
dosage agents
12
excretion lactulose
12
ascorbic
9
acid
8
dosage ascorbic
8
augmented excretion
8
6-hr period
8
healthy female
8
intestinal permeability
8
prevent aspirin-induced
8
aspirin-induced increase
8
female volunteers
8
aspirin
7
dosage
6
lactulose
5
consumption aspirin
4
lactulose 6-hr
4
augmented consumption
4

References

(Supplied by CrossRef)
Neutrophil function: from mechanisms to disease
Amulic et al.
Annu Rev Immunol 2012

Similar Publications