Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.

Nat Immunol 2015 Mar 26;16(3):306-17. Epub 2015 Jan 26.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

The recognized diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes have emerged, ILC1, ILC2 and ILC3, with ILC1 and ILC3 including several subsets. The classification of some subsets is unclear, and it remains controversial whether natural killer (NK) cells and ILC1 cells are distinct cell types. To address these issues, we analyzed gene expression in ILCs and NK cells from mouse small intestine, spleen and liver, as part of the Immunological Genome Project. The results showed unique gene-expression patterns for some ILCs and overlapping patterns for ILC1 cells and NK cells, whereas other ILC subsets remained indistinguishable. We identified a transcriptional program shared by small intestine ILCs and a core ILC signature. We revealed and discuss transcripts that suggest previously unknown functions and developmental paths for ILCs.

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http://dx.doi.org/10.1038/ni.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372143PMC
March 2015
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