J Cell Sci 2015 Feb 22;128(4):621-30. Epub 2015 Jan 22.
Department of Cell Biology, University of Alberta, Edmonton, AL T6G 2H7, Canada
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Biochim Biophys Acta 2016 May 24;1863(5):1014-8. Epub 2015 Nov 24.
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address:
Organelle inheritance is the process by which eukaryotic cells actively replicate and equitably partition their organelles between mother cell and daughter cell at cytokinesis to maintain the benefits of subcellular compartmentalization. The budding yeast Saccharomyces cerevisiae has proven invaluable in helping to define the factors involved in the inheritance of different organelles and in understanding how these factors act and interact to maintain balance in the organelle populations of actively dividing cells. Inheritance factors can be classified as motors that transport organelles, tethers that retain organelles, and connectors (receptors) that mediate the attachment of organelles to motors and anchors. Read More
Biochim Biophys Acta 2006 Dec 22;1763(12):1669-77. Epub 2006 Aug 22.
Department of Cell Biology, University of Alberta, Medical Sciences Building 5-14, Edmonton, Alberta, Canada T6G 2H7.
Eukaryotic cells have evolved molecular mechanisms to ensure the faithful partitioning of cellular components during cell division. The budding yeast Saccharomyces cerevisiae has to actively deliver about half of its organelles to the growing bud, while retaining the remaining organelles in the mother cell. Until lately, little was known about the inheritance of peroxisomes. Read More
Dev Cell 2006 May;10(5):587-600
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
The faithful inheritance of organelles by daughter cells is essential to maintain the benefits afforded to eukaryotic cells by compartmentalization of biochemical functions. In Saccharomyces cerevisiae, the class V myosin, Myo2p, is involved in transporting different organelles, including the peroxisome, along actin cables to the bud. We identified Inp2p as the peroxisome-specific receptor for Myo2p. Read More
Nat Rev Mol Cell Biol 2010 Sep 18;11(9):644-54. Epub 2010 Aug 18.
Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
Preserving a functional set of cytoplasmic organelles in a eukaryotic cell requires a process of accurate organelle inheritance at cell division. Studies of peroxisome inheritance in yeast have revealed that polarized transport of a subset of peroxisomes to the emergent daughter cell is balanced by retention mechanisms operating in both mother cell and bud to achieve an equitable distribution of peroxisomes between them. It is becoming apparent that some common mechanistic principles apply to the inheritance of all organelles, but at the same time, inheritance factors specific for each organelle type allow the cell to differentially and specifically control the inheritance of its different organelle populations. Read More