Sharing the cell's bounty - organelle inheritance in yeast.

Authors:
Barbara Knoblach
Barbara Knoblach
University of Alberta
Canada
Richard A Rachubinski
Richard A Rachubinski
University of Alberta
Canada

J Cell Sci 2015 Feb 22;128(4):621-30. Epub 2015 Jan 22.

Department of Cell Biology, University of Alberta, Edmonton, AL T6G 2H7, Canada

Eukaryotic cells replicate and partition their organelles between the mother cell and the daughter cell at cytokinesis. Polarized cells, notably the budding yeast Saccharomyces cerevisiae, are well suited for the study of organelle inheritance, as they facilitate an experimental dissection of organelle transport and retention processes. Much progress has been made in defining the molecular players involved in organelle partitioning in yeast. Each organelle uses a distinct set of factors - motor, anchor and adaptor proteins - that ensures its inheritance by future generations of cells. We propose that all organelles, regardless of origin or copy number, are partitioned by the same fundamental mechanism involving division and segregation. Thus, the mother cell keeps, and the daughter cell receives, their fair and equitable share of organelles. This mechanism of partitioning moreover facilitates the segregation of organelle fragments that are not functionally equivalent. In this Commentary, we describe how this principle of organelle population control affects peroxisomes and other organelles, and outline its implications for yeast life span and rejuvenation.

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.151423DOI Listing
February 2015
2 Reads

Publication Analysis

Top Keywords

cell daughter
8
mother cell
8
daughter cell
8
organelle inheritance
8
organelle
7
fragments functionally
4
set factors
4
distinct set
4
functionally equivalent
4
factors motor
4
segregation organelle
4
anchor adaptor
4
adaptor proteins
4
organelle distinct
4
organelle fragments
4
motor anchor
4
partitioning yeast
4
progress defining
4
commentary describe
4
processes progress
4

Similar Publications

Sharing with your children: Mechanisms of peroxisome inheritance.

Biochim Biophys Acta 2016 May 24;1863(5):1014-8. Epub 2015 Nov 24.

Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address:

Organelle inheritance is the process by which eukaryotic cells actively replicate and equitably partition their organelles between mother cell and daughter cell at cytokinesis to maintain the benefits of subcellular compartmentalization. The budding yeast Saccharomyces cerevisiae has proven invaluable in helping to define the factors involved in the inheritance of different organelles and in understanding how these factors act and interact to maintain balance in the organelle populations of actively dividing cells. Inheritance factors can be classified as motors that transport organelles, tethers that retain organelles, and connectors (receptors) that mediate the attachment of organelles to motors and anchors. Read More

View Article
May 2016

Sharing the wealth: peroxisome inheritance in budding yeast.

Biochim Biophys Acta 2006 Dec 22;1763(12):1669-77. Epub 2006 Aug 22.

Department of Cell Biology, University of Alberta, Medical Sciences Building 5-14, Edmonton, Alberta, Canada T6G 2H7.

Eukaryotic cells have evolved molecular mechanisms to ensure the faithful partitioning of cellular components during cell division. The budding yeast Saccharomyces cerevisiae has to actively deliver about half of its organelles to the growing bud, while retaining the remaining organelles in the mother cell. Until lately, little was known about the inheritance of peroxisomes. Read More

View Article
December 2006

The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae.

Dev Cell 2006 May;10(5):587-600

Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

The faithful inheritance of organelles by daughter cells is essential to maintain the benefits afforded to eukaryotic cells by compartmentalization of biochemical functions. In Saccharomyces cerevisiae, the class V myosin, Myo2p, is involved in transporting different organelles, including the peroxisome, along actin cables to the bud. We identified Inp2p as the peroxisome-specific receptor for Myo2p. Read More

View Article
May 2006

Molecular mechanisms of organelle inheritance: lessons from peroxisomes in yeast.

Nat Rev Mol Cell Biol 2010 Sep 18;11(9):644-54. Epub 2010 Aug 18.

Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.

Preserving a functional set of cytoplasmic organelles in a eukaryotic cell requires a process of accurate organelle inheritance at cell division. Studies of peroxisome inheritance in yeast have revealed that polarized transport of a subset of peroxisomes to the emergent daughter cell is balanced by retention mechanisms operating in both mother cell and bud to achieve an equitable distribution of peroxisomes between them. It is becoming apparent that some common mechanistic principles apply to the inheritance of all organelles, but at the same time, inheritance factors specific for each organelle type allow the cell to differentially and specifically control the inheritance of its different organelle populations. Read More

View Article
September 2010