J Renal Inj Prev 2014 1;3(4):109-10. Epub 2014 Dec 1.
Chronic Renal Failure Research Center, Department of Internal Medicine, Ahvaz University of Medical Sciences, Ahvaz, Iran.
Environ Pollut 2021 Feb 16;277:116750. Epub 2021 Feb 16.
Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. Electronic address:
We used real-world exposure scenarios to evaluate the effect of six ambient air pollutant (PM, PM, NO, SO, CO, and O) exposure on renal function among older adults without chronic kidney disease (CKD). We recruited 169 older adults without CKD in Beijing, China, for a longitudinal study from 2016 to 2018. The Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (EPI) equations were employed to derive the estimated glomerular filtration rate (eGFR). Read More
Pharmacol Res 2021 Mar 3:105530. Epub 2021 Mar 3.
Department of Medicine and Rehabilitation, Policlinico di Monza, Monza, Italy; Department of Medicine and Surgery, University of Milano Bicocca, Milan, Italy. Electronic address:
Background: Sodium glucose transporter 2 inhibitors (SGLT2-i) reduce renal and cardiovascular events in patients with type 2 diabetes (T2D) and their use is recommended by the 2020 KDIGO guidelines in patients with T2D and chronic kidney disease (CKD). The aim of this study is to estimate the proportion of patients with T2D and CKD in the US that should be treated with these agents for renal and cardiovascular protection.Methods: We conducted a retrospective analysis of 2005-2018 National Health and Nutrition Examination Survey (NHANES) data. Read More
J Steroid Biochem Mol Biol 2021 Mar 3:105861. Epub 2021 Mar 3.
Department of Health Sciences, University of Leicester, United Kingdom.
Background: Evidence is growing for a role of vitamin D in regulating skeletal muscle mass, strength and functional capacity. Given the role the kidneys play in activating total vitamin D, and the high prevalence of vitamin D deficiency in Chronic Kidney Disease (CKD), it is possible that deficiency contributes to the low levels of physical function and muscle mass in these patients.Methods: This is a secondary cross-sectional analysis of previously published interventional study, within vitro follow up work. Read More
Kidney Int 2021 Mar 3. Epub 2021 Mar 3.
Université de Paris, PARCC, Inserm, F-75015 Paris, France. Electronic address:
The strong predictive value of proteinuria in chronic glomerulopathies is firmly established as well as the pathogenic role of angiotensin II promoting progression of glomerular disease with an altered glomerular filtration barrier, podocyte injury and scarring of glomeruli. Here we found that chronic angiotensin II-induced hypertension inhibited autophagy flux in mouse glomeruli. Deletion of Atg5 (a gene encoding a protein involved autophagy) specifically in the podocyte resulted in accelerated angiotensin II-induced podocytopathy, accentuated albuminuria and glomerulosclerosis. Read More
The Institute of Cardiovascular Sciences, Institute of Systems Biomedicine, School of Basic Medical Sciences; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Beijing Key Laboratory of Cardiovascular Receptors Research; Peking University Health Science Center; Beijing 100191, China; China National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, Beijing 100050, China.. Electronic address:
Since failed resolution of inflammation is a major contributor to the progression of diabetic nephropathy, identifying endogenously generated molecules that promote the physiological resolution of inflammation may be a promising therapeutic approach for this disease. Annexin A1 (ANXA1), as an endogenous mediator, plays an important role in resolving inflammation. Whether ANXA1 could affect established diabetic nephropathy through modulating inflammatory states remains largely unknown. Read More