A comparison of two different culture methods for use in the diagnosis of pulmonary tuberculosis.

Eurasian J Med 2014 Jun;46(2):74-7

Department of Pulmonary Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Objective: Tuberculosis (TB) continues to be a significant health problem worldwide. Pulmonary TB is a contagious disease. To control the spread of TB, the disease must be diagnosed early and treated effectively.

Materials And Methods: In this study, we determined the rates and periods of TB bacterial reproduction using the Lowenstein-Jensen (LJ) and the Mycobacterium Growth Indicator Tube (MGIT) culture systems in respiratory specimens obtained from 105 suspected TB cases that applied to our service.

Results: Using either the LJ or MGIT method, the reproduction rates of TB cultures from 91 positively diagnosed cases were determined to be 69.2% and 92.3% (p=0.116), respectively. The reproduction period for these same cultures was determined to be 29.7±10.0 days and 12.1±6.1 days (p<0.0001), respectively. The culture positivity rate determined using both the LJ and MGIT methods together was found to be significantly higher than the rate determined using either LJ or MGIT separately (p<0.0001).

Conclusion: For the early diagnosis of pulmonary tuberculosis, which is essential for controlling the spread of TB, the routine use of the MGIT system, which is a rapid, automated and non-radiometric method, combined with the LJ method would effectively increase the diagnosis rate in order to control tuberculosis outbreaks.

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Source
http://dx.doi.org/10.5152/eajm.2014.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261448PMC
June 2014
1 Citation

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