The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease.

Authors:
Prof Ahmad Salehi, M.D., Ph.D.
Prof Ahmad Salehi, M.D., Ph.D.
Stanford University School of Medicine
Professor
Palo Alto, CA | United States
Dr.  Cristy Phillips, PT, MSPT, SCCD, EdD
Dr. Cristy Phillips, PT, MSPT, SCCD, EdD
Arkansas State University
Assistant Professor
Rehabilitation
Jonesboro , AR | United States
Dr Mehmet Akif Baktir, MD
Dr Mehmet Akif Baktir, MD
Stanford University School of Medicine
Visiting Researcher
Physiology
Turkey

Phys Ther 2015 Jul 8;95(7):1046-60. Epub 2015 Jan 8.

A. Salehi, MD, PhD, VA Palo Alto Health Care System and Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University.

Alzheimer disease (AD) is a primary cause of cognitive dysfunction in the elderly population worldwide. Despite the allocation of enormous amounts of funding and resources to studying this brain disorder, there are no effective pharmacological treatments for reducing the severity of pathology and restoring cognitive function in affected people. Recent reports on the failure of multiple clinical trials for AD have highlighted the need to diversify further the search for new therapeutic strategies for cognitive dysfunction. Thus, studies detailing the neuroprotective effects of physical activity (PA) on the brain in AD were reviewed, and mechanisms by which PA might mitigate AD-related cognitive decline were explored. A MEDLINE database search was used to generate a list of studies conducted between January 2007 and September 2014 (n=394). These studies, along with key references, were screened to identify those that assessed the effects of PA on AD-related biomarkers and cognitive function. The search was not limited on the basis of intensity, frequency, duration, or mode of activity. However, studies in which PA was combined with another intervention (eg, diet, pharmacotherapeutics, ovariectomy, cognitive training, behavioral therapy), and studies not written in English were excluded. Thirty-eight animal and human studies met entry criteria. Most of the studies suggested that PA attenuates neuropathology and positively affects cognitive function in AD. Although the literature lacked sufficient evidence to support precise PA guidelines, convergent evidence does suggest that the incorporation of regular PA into daily routines mitigates AD-related symptoms, especially when deployed earlier in the disease process. Here the protocols used to alter the progression of AD-related neuropathology and cognitive decline are highlighted, and the implications for physical therapist practice are discussed.

Download full-text PDF

Source
http://dx.doi.org/10.2522/ptj.20140212DOI Listing
July 2015
58 Reads
12 Citations
2.530 Impact Factor

Publication Analysis

Top Keywords

cognitive function
12
cognitive dysfunction
12
cognitive
9
cognitive decline
8
physical activity
8
alzheimer disease
8
studies
7
september 2014
4
2014 n=394
4
convergent evidence
4
2007 september
4
guidelines convergent
4
january 2007
4
conducted january
4
precise guidelines
4
studies key
4
screened identify
4
sufficient evidence
4
identify assessed
4
references screened
4

References

(Supplied by CrossRef)

California Workgroup on Guidelines for Alzheimer's Disease Management et al.
2008

Salehi et al.
2007

Williams et al.
2010
Regenerative medicine in Alzheimer's disease
Felsenstein et al.
Transl Res 2014
Brain health and exercise in older adults
Gregory et al.
Curr Sports Med Rep 2013
A review of the effects of physical activity and exercise on cognitive and brain functions in older adults
Bherer et al.
J Aging Res 2013

Similar Publications