Brain 2015 Mar 6;138(Pt 3):798-811. Epub 2015 Jan 6.
1 Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Portugal 5 ICNAS, Brain Imaging Network of Portugal
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Int J Neuropsychopharmacol 2018 Jan;21(1):42-58
Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom.
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder, distributed network perturbation appears focused around the prefrontal cortex, caudate, putamen, and associated neuro-circuitry. Read More
Arch Gen Psychiatry 2004 Jun;61(6):564-76
Department of Psychological Medicine, Institute of Psychiatry, London, England.
Context: Obsessive-compulsive disorder (OCD) is clinically heterogeneous, yet most previous functional neuroimaging studies grouped together patients with mixed symptoms, thus potentially reducing the power and obscuring the findings of such studies.
Objective: To investigate the neural correlates of washing, checking, and hoarding symptom dimensions in OCD.
Design: Symptom provocation paradigm, functional magnetic resonance imaging, block design, and nonparametric brain mapping analyses. Read More
Biol Psychiatry 2017 04 11;81(8):708-717. Epub 2016 Aug 11.
Departments of Psychology, University of Cambridge, Cambridge; Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge.
Background: A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and cognitive flexibility to underlying resting-state functional connectivity.
Methods: Multiecho resting-state acquisition, combined with micromovement correction by blood oxygen level-dependent sensitive independent component analysis, was used to obtain in vivo measures of functional connectivity in 44 OCD patients and 43 healthy comparison subjects. Read More
Eur Psychiatry 2017 10 1;46:25-32. Epub 2017 Sep 1.
Department of psychiatry, Icahn school of medicine, 1425, Madison avenue, 10029 New York, Mount Sinai, USA. Electronic address:
Obsessive compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive ritualistic behaviors and has been associated with diverse functional brain abnormalities. We sought to synthesize current evidence from functional magnetic resonance imaging (fMRI) studies and examine their alignment to pathogenetic models of OCD. Following systematic review, we identified 54 task-fMRI studies published in the last decade comparing adults with OCD (n=1186) to healthy adults (n=1159) using tasks of affective and non-affective cognition. Read More