Controlled release of nafcillin using biocompatible "dummy" molecularly imprinted sol-gel nanospheres.

Curr Top Med Chem 2015 ;15(3):262-70

Faculty of Chemistry, Department of Physical and Analytical Chemistry, University of Oviedo. Av. Julian Claveria, 8 33006-Oviedo, Spain.

Different silicon-based xero-gel molecularly imprinted spheres in the nano boundary range with recognition capabilities for nafcillin have been synthesised, using tetraethylorthosilicate (TEOS) and (3- aminopropyl) triethoxysilane (APTEOS) as precursors. Imprinting has been achieved using both nafcillin (NAF) or structural analogous 'dummies' such as (+)-6-aminopenicillenic acid (APA), or ampicillin ((+)-6- aminobenzylpenicillin)sodium salt (AMP). Materials were fully characterized using ATR-FTIR, (29)Si solidstate NMR, TGA, TEM and BET. Adsorption isotherms for all the materials fit with a continuous Freundlich model with correlation coefficients better than 0.988 and mean affinity constants between 10(5) and 10(6) L·mol(-1). The use of 'dummies' as well as the template itself in the imprinting process resulted in materials with different release speed. Combinations of these materials allow designing mixtures with a continuous, controlled and constant release longer than four days. Thus, the non-imprinted and the AMP-imprinted material have a rapid release during the first five hours, nafcillin and APA imprinted ones release antibiotic mainly after a latency-period of 24 hours.

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http://dx.doi.org/10.2174/1568026614666141229113630DOI Listing
October 2015
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