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    Childhood hypopigmented mycosis fungoides: a commonly delayed diagnosis.
    BMJ Case Rep 2014 Dec 23;2014. Epub 2014 Dec 23.
    Coimbra University Hospital, Coimbra, Portugal.
    Primary cutaneous lymphomas (PCLs) are exceedingly rare in children and adolescents, with mycosis fungoides (MF) being the most frequent PCL diagnosed in childhood. There are numerous unusual clinical variants of MF, including the hypopigmented type form (HMF). HMF is exceptional overall, but comparatively common among children. We present an 8-year-old boy with a 3-year history of progressive, generalised, scaly, hypopigmented round patches and few erythematous papules. He was first diagnosed with pityriasis alba (PA), and moisturisers were prescribed with no improvement. Skin biopsy showed typical features of MF, and the patient was successfully treated with narrowband ultraviolet B. HMF may simulate atopic dermatitis, PA, pityriasis lichenoides, tinea versicolour, vitiligo, postinflammatory hypopigmentation or leprosy. Therefore, persistent and unusual hypopigmented lesions should be biopsied to rule out this rare variant of MF.

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    Hypopigmented mycosis fungoides: a clinical mimicker of vitiligo.
    J Drugs Dermatol 2015 Feb;14(2):193-4
    Hypopigmented mycosis fungoides (HMF) is a rare variant of cutaneous T-cell lymphoma (CTCL) that often manifests in younger patients with darker skin types in a centripetal distribution.(1) Average age of diagnosis is often 14 years.(2) The diagnosis is often missed due to its low incidence and lack of clinical suspicion. Read More
    Hypopigmented mycosis fungoides versus mycosis fungoides with concomitant hypopigmented lesions: same disease or different variants of mycosis fungoides?
    Dermatology 2014 11;229(3):271-4. Epub 2014 Oct 11.
    Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Background: Hypopigmented mycosis fungoides (HMF) is a rare subtype of mycosis fungoides (MF). We compared patients with exclusive hypopigmented lesions with a group of MF patients with concomitant different lesions.

    Methods: 20 patients with HMF only and 14 patients with hypopigmented lesions concomitant with other types of lesions (mixed MF, MMF) were selected. Read More
    Pityriasis lichenoides-like mycosis fungoides in children.
    Br J Dermatol 2000 Feb;142(2):347-52
    Department of Dermatology, Kosin Medical Center, Pusan, South Korea.
    We report three children with clinical features of pityriasis lichenoides (scaly red to brown papules and macules) in whom there were histopathological findings of mycosis fungoides (disproportionate epidermotropism, Pautrier's microabscesses, and wiry and coarse collagen bundles). Immunohistochemical staining revealed a prevalence of T lymphocytes in the infiltrate. T-cell receptor gene rearrangement analysis in lesional skin demonstrated rearrangement of the gamma chain in all cases. Read More
    Childhood Hypopigmented Mycosis Fungoides: A Rare Diagnosis.
    Case Rep Pediatr 2016 29;2016:8564389. Epub 2016 Nov 29.
    Pediatrics Department, Portuguese Oncology Institute of Porto Francisco Gentil, 4200-072 Porto, Portugal.
    Primary cutaneous lymphomas (PCL) are rare in pediatrics. Mycosis fungoides (MF) is the most frequent PCL diagnosed in childhood. There are various clinical variants of MF, including the hypopigmented MF (HMF). Read More