Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis.

J Am Heart Assoc 2014 Dec;3(6):e001202

Division of Cardiology, Emory University School of Medicine, Atlanta, GA

Background: Clinical studies show that metformin attenuates all‐cause mortality and myocardial infarction compared with other medications for type 2 diabetes, even at similar glycemic levels. However, there is paucity of data in the euglycemic state on the vasculoprotective effects of metformin. The objectives of this study are to evaluate the effects of metformin on ameliorating atherosclerosis.

Methods And Results: Using ApoE−/− C57BL/6J mice, we found that metformin attenuates atherosclerosis and vascular senescence in mice fed a high‐fat diet and prevents the upregulation of angiotensin II type 1 receptor by a high‐fat diet in the aortas of mice. Thus, considering the known deleterious effects of angiotensin II mediated by angiotensin II type 1 receptor, the vascular benefits of metformin may be mediated, at least in part, by angiotensin II type 1 receptor downregulation. Moreover, we found that metformin can cause weight loss without hypoglycemia. We also found that metformin increases the antioxidant superoxide dismutase‐1.

Conclusion: Pleiotropic effects of metformin ameliorate atherosclerosis and vascular senescence.

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Source
https://www.ahajournals.org/doi/10.1161/JAHA.114.001202
Publisher Site
http://dx.doi.org/10.1161/JAHA.114.001202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338706PMC
December 2014
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References

(Supplied by CrossRef)
Lipids, lipoproteins, atherosclerosis and cardiovascular disease
Burnett JR et al.
Clin Biochem Rev 2004

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