Am J Psychiatry 2015 Mar 19;172(3):284-93. Epub 2014 Dec 19.
From the Departments of Psychology and Psychiatry, and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom; the Department of Psychology at New York University, New York; South Essex Partnership University NHS Foundation Trust, Springhouse, Biggleswade Hospital, Bedfordshire, United Kingdom; the Department of Psychiatry, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, United Kingdom; and the Postgraduate Medical School, University of Hertfordshire, Hatfield, United Kingdom.
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Biol Psychiatry 2014 Apr 16;75(8):631-8. Epub 2013 Mar 16.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge; Department of Psychology, University of Cambridge, Cambridge.
Background: Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensitive to goal value. We tested if OCD patients have a bias toward habits using a novel shock avoidance task. Read More
Arch Gen Psychiatry 2006 Nov;63(11):1225-36
Department of Psychiatry, VU University Medical Center, Graduate School of Neurosciences, and Outpatient Academic Clinic for Anxiety Disorders, GGZ Buitenamstel, Amsterdam, the Netherlands.
Context: The orbitofrontal cortex (OFC)-striatal circuit, which is important for motivational behavior, is assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD) according to current neurobiological models of this disorder. However, the engagement of this neural loop in OCD has not been tested directly in a cognitive activation imaging paradigm so far.
Objective: To determine whether the OFC and the ventral striatum show abnormal neural activity in OCD during cognitive challenge. Read More
Brain 2015 Mar 6;138(Pt 3):798-811. Epub 2015 Jan 6.
1 Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Portugal 5 ICNAS, Brain Imaging Network of Portugal
Intrusive thoughts and compulsive urges to perform stereotyped behaviours are typical symptoms of obsessive-compulsive disorder. Emerging evidence suggests a cognitive bias towards habit formation at the expense of goal-directed performance in obsessive-compulsive disorder. In this study, we test this hypothesis using a novel individualized ecologically valid symptom provocation design: a live provocation functional magnetic resonance imaging paradigm with synchronous video-recording of behavioural avoidance responses. Read More
Arch Gen Psychiatry 2009 Nov;66(11):1189-200
Institut d'Alta Tecnologia-Parc de Recerca Biomèdica de Barcelona, Centro Radiológico Computerizado Corporació Sanitària, Barcelona, Spain.
Context: Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain corticostriatal networks, or "loops." Although neuroimaging studies of patients have supported this network model of OCD, very few have applied measurements that are sensitive to brain connectivity features.
Objective: Using resting-state functional magnetic resonance imaging, we tested the hypothesis that OCD is associated with disturbances in the functional connectivity of primarily ventral corticostriatal regions, measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal. Read More