Long non-coding RNAs as emerging regulators of differentiation, development, and disease.

Transcription 2014 30;5(4):e944014. Epub 2014 Oct 30.

a Department of Biochemistry and Molecular Genetics ; University of Virginia School of Medicine ; Charlottesville , VA USA.

A significant portion of the mammalian genome encodes numerous transcripts that are not translated into proteins, termed long non-coding RNAs. Initial studies identifying long non-coding RNAs inferred these RNA sequences were a consequence of transcriptional noise or promiscuous RNA polymerase II activity. However, the last decade has seen a revolution in the understanding of regulation and function of long non-coding RNAs. Now it has become apparent that long non-coding RNAs play critical roles in a wide variety of biological processes. In this review, we describe the current understanding of long non-coding RNA-mediated regulation of cellular processes: differentiation, development, and disease.

Download full-text PDF

Source
http://dx.doi.org/10.4161/21541272.2014.944014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581346PMC
July 2015
21 Reads

Publication Analysis

Top Keywords

long non-coding
24
non-coding rnas
20
differentiation development
8
development disease
8
long
6
non-coding
5
rnas
5
variety biological
4
consequence transcriptional
4
promiscuous rna
4
transcriptional noise
4
noise promiscuous
4
biological processes
4
identifying long
4
studies identifying
4
rnas inferred
4
inferred rna
4
rna sequences
4
wide variety
4
sequences consequence
4

Similar Publications