Search our Database of Scientific Publications and Authors

I’m looking for a
    Cytotoxic constituents of Abutilon indicum leaves against U87MG human glioblastoma cells.
    Nat Prod Res 2015 25;29(11):1069-73. Epub 2014 Nov 25.
    a Department of Pharmacy , BITS-Pilani Hyderabad Campus, Jawahar Nagar, Shamirpet Mandal, Hyderabad 500 078 , Telangana , India.
    The study was aimed to identify cytotoxic leads from Abutilon indicum leaves for treating glioblastoma. The petroleum ether extract, methanol extract (AIM), chloroform and ethyl acetate sub-fractions (AIM-C and AIM-E, respectively) prepared from AIM were tested for cytotoxicity on U87MG human glioblastoma cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. These extracts exhibited considerable activity (IC50 values of 42.6-64.5 μg/mL). The most active AIM-C fraction was repeatedly chromatographed to yield four known compounds, methyl trans-p-coumarate (1), methyl caffeate (2), syringic acid (3) and pinellic acid (4). Cell viability assay of 1-4 against U87MG cells indicated 2 as most active (IC50 value of 8.2 μg/mL), whereas the other three compounds were much less active. Interestingly, compounds 1-4 were non-toxic towards normal human cells (HEK-293). The content of 2 in AIM-C was estimated as 3% by HPLC. Hence, presence of some more active substances besides methyl caffeate (2) in AIM-C is anticipated.

    Similar Publications

    Antioxidant potential and radical scavenging effects of various extracts from Abutilon indicum and Abutilon muticum.
    Pharm Biol 2010 Mar;48(3):282-9
    Center for Natural Product Research, Department of Chemistry, GC University, Lahore, Pakistan.
    Abutilon indicum L. (Malvaceae) and Abutilon muticum DC. (Malvaceae) are traditional medicinal herbs used for analgesic, anthelmintic, hepatoprotective, and hypoglycemic properties. Read More
    Biogenic silver nanoparticles from Abutilon indicum: their antioxidant, antibacterial and cytotoxic effects in vitro.
    Colloids Surf B Biointerfaces 2015 Apr 7;128:276-86. Epub 2015 Feb 7.
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, India. Electronic address:
    Green synthesis of silver nanoparticles using biological entities is gaining interest because of their potential applications in nano-medicine. Herein, we report the biological synthesis of Abutilon indicum silver nanoparticles (AIAgNPs) using aqueous Abutilon indicum leaf extract (AILE) and evaluation of their biological applications. TEM analysis revealed that the spherical biogenic AIAgNPs were found to be between 5 and 25 nm in size. Read More
    Studies on cytotoxic constituents from the leaves of Elaeagnus oldhamii Maxim. in non-small cell lung cancer A549 cells.
    Molecules 2014 Jul 4;19(7):9515-34. Epub 2014 Jul 4.
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan.
    Elaeagnus oldhamii Maxim. is a commonly used traditional herbal medicine. In Taiwan the leaves of E. Read More
    Cytotoxicity of Marchantia convoluta leaf extracts to human liver and lung cancer cells.
    Braz J Med Biol Res 2006 Jun 2;39(6):731-8. Epub 2006 Jun 2.
    College of Chemistry and Chemical Engineering, Central South University, Changsha, China.
    The cytotoxicity of three extracts (petroleum ether, ethyl acetate and n-butanol) from a plant used in folk medicine, Marchantia convoluta, to human non-small cell lung carcinoma (H1299) and liver carcinoma (HepG2) cell lines was tested. After 72-h incubation of lung and liver cancer cell cultures with varying concentrations of extracts (15 to 200 microg/mL), cytotoxicity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and reported in terms of cell viability. The extracts that showed a significant cytotoxicity were subjected to gas chromatography-mass spectrometry analysis to identify the components. Read More