K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

J Infect Dis 2015 Apr 2;211(8):1352-5. Epub 2014 Nov 2.

Wellcome Trust Sanger Institute, Hinxton Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Mali.

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

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http://dx.doi.org/10.1093/infdis/jiu608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827505PMC
April 2015
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