The SAPHO syndrome revisited with an emphasis on spinal manifestations.

Authors:
Antonio Leone
Antonio Leone
Institute of Cardiology
Roberto Casale
Roberto Casale
Scientific Institute of Montescano
Italy
Nicola Magarelli
Nicola Magarelli
Catholic University
Italy
Alessia Semprini
Alessia Semprini
Institute of Radiology
United Kingdom
Cesare Colosimo
Cesare Colosimo
Institute of Neurology
Italy

Skeletal Radiol 2015 Jan 21;44(1):9-24. Epub 2014 Oct 21.

Department of Radiological Sciences, Catholic University, School of Medicine, Largo A. Gemelli 1, 00168, Rome, Italy,

The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome includes a group of chronic, relapsing, inflammatory musculoskeletal disorders with similar manifestations, in particular synovitis, hyperostosis, and osteitis, which may or may not be associated with neutrophilic skin eruptions such as palmoplantar pustulosis and acne conglobata. The syndrome occurs at any age, can involve any skeletal site, and its imaging appearances are variable, depending on the stage/age of the lesion and imaging method. The diagnosis is difficult if there is no skin disease. Awareness of the imaging appearances, especially in the spine, may help the radiologist in avoiding misdiagnosis (e.g., infection, tumor) and unnecessary invasive procedures, while facilitating early diagnosis and selection of an effective treatment. In this article, we provide an overview of the radiological appearances of SAPHO syndrome, focusing on the magnetic resonance imaging findings of vertebral involvement, and present relevant clinical and pathological features that assist early diagnosis.

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http://dx.doi.org/10.1007/s00256-014-2025-0DOI Listing
January 2015
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