The SAPHO syndrome revisited with an emphasis on spinal manifestations.

Authors:
Antonio Leone
Antonio Leone
Institute of Cardiology
Roberto Casale
Roberto Casale
Scientific Institute of Montescano
Italy
Nicola Magarelli
Nicola Magarelli
Catholic University
Italy
Alessia Semprini
Alessia Semprini
Institute of Radiology
United Kingdom
Cesare Colosimo
Cesare Colosimo
Institute of Neurology
Italy

Skeletal Radiol 2015 Jan 21;44(1):9-24. Epub 2014 Oct 21.

Department of Radiological Sciences, Catholic University, School of Medicine, Largo A. Gemelli 1, 00168, Rome, Italy,

The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome includes a group of chronic, relapsing, inflammatory musculoskeletal disorders with similar manifestations, in particular synovitis, hyperostosis, and osteitis, which may or may not be associated with neutrophilic skin eruptions such as palmoplantar pustulosis and acne conglobata. The syndrome occurs at any age, can involve any skeletal site, and its imaging appearances are variable, depending on the stage/age of the lesion and imaging method. The diagnosis is difficult if there is no skin disease. Awareness of the imaging appearances, especially in the spine, may help the radiologist in avoiding misdiagnosis (e.g., infection, tumor) and unnecessary invasive procedures, while facilitating early diagnosis and selection of an effective treatment. In this article, we provide an overview of the radiological appearances of SAPHO syndrome, focusing on the magnetic resonance imaging findings of vertebral involvement, and present relevant clinical and pathological features that assist early diagnosis.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00256-014-2025-0DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
January 2015
8 Reads

Publication Analysis

Top Keywords

sapho syndrome
12
imaging appearances
8
hyperostosis osteitis
8
early diagnosis
8
manifestations synovitis
8
appearances variable
4
focusing magnetic
4
syndrome focusing
4
variable depending
4
stage/age lesion
4
appearances sapho
4
method diagnosis
4
imaging method
4
lesion imaging
4
depending stage/age
4
imaging
4
diagnosis selection
4
syndrome occurs
4
imaging findings
4
conglobata syndrome
4

References

(Supplied by CrossRef)
Article in Arthritis Rheum
RE Windom et al.
Arthritis Rheum 1961
Article in Seikei Geka
T Kato et al.
Seikei Geka 1968
Article in Ann Radiol (Paris)
A Giedion et al.
Ann Radiol (Paris) 1972
Article in Dtsch Med Wochenschr
H Köhler et al.
Dtsch Med Wochenschr 1975
Article in J Pediatr
B Björkstén et al.
J Pediatr 1978
Article in Dermatologica
K Bergdahl et al.
Dermatologica 1979
Article in Arch Orthop Trauma Surg
H Sonozaki et al.
Arch Orthop Trauma Surg 1979
Article in Ann Rheum Dis
H Sonozaki et al.
Ann Rheum Dis 1981
Article in Clin Rheumatol
W Dihlmann et al.
Clin Rheumatol 1991
Article in Mayo Clin Proc
NM Lindor et al.
Mayo Clin Proc 1997
Article in Pediatr Dermatol
BE Tlougan et al.
Pediatr Dermatol 2009

Similar Publications