Consensus of clinical neurorestorative progress in patients with complete chronic spinal cord injury.

Authors:
Hongyun Huang
Hongyun Huang
Center for Neurorestoratology
Tiansheng Sun
Tiansheng Sun
Beijing Army General Hospital
China
Lin Chen
Lin Chen
University of Minnesota Medical School
China
Gustavo Moviglia
Gustavo Moviglia
Center for Research in Tissue Engineering and Cellular Therapies
Elena Chernykh
Elena Chernykh
Laboratory of Cellular Immunotherapy
Haluk Deda
Haluk Deda
Akay Hospital
Kyung-Sun Kang
Kyung-Sun Kang
South Korea

Cell Transplant 2014 9;23 Suppl 1:S5-17. Epub 2014 Oct 9.

Center of Neurorestoratology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.

Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. These strategies include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization or nerve bridging, and neurorehabilitation. The aim of this consensus by 31 experts from 20 countries is to show the objective evidence of clinical neurorestoration for chronic complete SCI by the mentioned neurorestorative strategies. Complete chronic SCI patients are no longer told, "nothing can be done." The clinical translation of more effective preclinical neurorestorative strategies should be encouraged as fast as possible in order to benefit patients with incurable CNS diseases. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.

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August 2015
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