CSF and plasma amyloid-β temporal profiles and relationships with neurological status and mortality after severe traumatic brain injury.

Sci Rep 2014 Oct 10;4:6446. Epub 2014 Oct 10.

Quanterix Corporation, 113 Hartwell Ave., Lexington, MA, USA.

The role of amyloid-β (Aβ) neuropathology and its significant changes in biofluids after traumatic brain injury (TBI) is still debated. We used ultrasensitive digital ELISA approach to assess amyloid-β1-42 (Aβ42) concentrations and time-course in cerebrospinal fluid (CSF) and in plasma of patients with severe TBI and investigated their relationship to injury characteristics, neurological status and clinical outcome. We found decreased CSF Aβ42 levels in TBI patients acutely after injury with lower levels in patients who died 6 months post-injury than in survivors. Conversely, plasma Aβ42 levels were significantly increased in TBI with lower levels in patients who survived. A trend analysis showed that both CSF and plasma Aβ42 levels strongly correlated with mortality. A positive correlation between changes in CSF Aβ42 concentrations and neurological status as assessed by Glasgow Coma Scale (GCS) was identified. Our results suggest that determination of Aβ42 may be valuable to obtain prognostic information in patients with severe TBI as well as in monitoring the response of the brain to injury.

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http://dx.doi.org/10.1038/srep06446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192636PMC
October 2014
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