Get 20% Off Journals at LWW.com

Alternating expression levels of tumor suppressor and cancer-related genes in patients with bladder cancer.

Oncol Lett 2014 Nov 22;8(5):2291-2297. Epub 2014 Aug 22.

Department of Molecular Cancerogenesis, Medical University of Lodz, Lodz 90-752, Poland.

The aim of the present study was to determine the roles of the tumor suppressor and cancer-related genes in bladder tumor carcinogenesis. Reverse transcription-quantitative polymerase chain reaction was used to analyze the status of promoter methylation (using MethylScreen™ technology) and loss of heterozygosity (LOH) in papillary urothelial cancer tissues. The associations between the expression levels of the following tumorigenesis-related genes were also assessed: The tumor suppressor gene the proliferation gene, the and apoptotic genes, the signal transduction gene, the vascular endothelial growth factor gene, and the and cell cycle genes. The results reveal a high frequency of LOH in intron 1 in the gene, as well as an association between reduced expression levels and increased promoter methylation. In addition, the present study demonstrates that in bladder tumors, apoptosis is inhibited by increased expression levels of the gene. A correlation between the proliferation indices of the and the genes was also revealed Furthermore, the expression levels of were identified to be positively associated with those of the gene.

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2014.2476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186597PMC
November 2014
Save 15% Survey

Similar Publications

Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis.

Oncol Rep 2012 Oct 27;28(4):1417-22. Epub 2012 Jul 27.

Department of Molecular Cancerogenesis, Medical University of Lodz, 90-752 Lodz, Poland.

Loss of heterozygosity (LOH) in 16q appears in ~20-30% cases of Wilms' tumor. Within this region, known as common fragile site FRA16D, the WWOX tumor suppressor gene is located. Abnormalities of WWOX gene expression levels were observed in many tumor types and were associated with worse prognosis. Read More

View Article and Full-Text PDF
October 2012

The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study.

Acta Biochim Pol 2014 22;61(1):91-7. Epub 2014 Jan 22.

Department of Molecular Cancerogenesis, Medical University of Lodz, Łódź, Poland.

Neuroblastoma is one of the most common paediatric cancers, described as unpredictable due to diverse patterns of behaviour. WWOX is a tumour suppressor gene whose expression is reduced in many tumour types. Loss of its expression was shown to correlate with more aggressive disease stage and mortality rate. Read More

View Article and Full-Text PDF
November 2014

The WWOX tumor suppressor gene in endometrial adenocarcinoma.

Int J Mol Med 2013 Dec 11;32(6):1458-64. Epub 2013 Oct 11.

Department of Molecular Cancerogenesis, Medical University of Lodz, PL 90-752 Lodz, Poland.

Endometrial cancer is a lethal malignancy, the causes of which remain to be determined. The aim of the present study, carried out on tumor samples from 79 patients, was to evaluate the role of the WWOX tumor suppressor gene in endometrial adenocarcinoma. The expression levels of WWOX and its protein content were assessed in normal endometrium and cancer samples. Read More

View Article and Full-Text PDF
December 2013

The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.

Clin Cancer Res 2004 Apr;10(7):2459-65

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Purpose: WWOX (WW domain containing oxidoreductase) is a tumor suppressor gene that maps to the common fragile site FRA16D. We showed previously that WWOX is frequently altered in human lung and esophageal cancers. The purpose of this study was to delineate more precisely the role of WWOX in pancreatic carcinogenesis. Read More

View Article and Full-Text PDF
April 2004