Spontaneous remission of acute myeloid leukemia.

Leuk Lymphoma 2015 Jun 3;56(6):1727-34. Epub 2014 Nov 3.

Division of Oncology, Washington University School of Medicine , St. Louis, MO , USA.

Spontaneous remission (SR) of acute myeloid leukemia (AML) is rare. We collected all 46 reported cases of AML with SR. Fever occurred in 91.3% of cases before remission, which was largely due to pneumonia (54.5%) and bacteremia (24.2%). Pneumonia and bacteremia were significantly more common among those who achieved complete remission (CR) compared to those who achieved only a partial remission (p = 0.032). Although 88.6% of remissions were CR, the median duration of remission was only 5 months. Eight cases did not relapse during the follow-up period. The mechanism of SR in AML likely involves the stimulatory effect of systemic febrile infection on the immune system. Immediate treatment of infections and fever may contribute to the rarity of SR in AML. The results of this review improve our understanding of the important role of the immune system in countermanding AML and may provide new ideas for immunotherapy.

Download full-text PDF

Source
http://dx.doi.org/10.3109/10428194.2014.970545DOI Listing
June 2015

Publication Analysis

Top Keywords

acute myeloid
8
remission acute
8
myeloid leukemia
8
spontaneous remission
8
immune system
8
remission
5
aml
5
886% remissions
4
0032 886%
4
review improve
4
remissions median
4
median duration
4
remission months
4
duration remission
4
improve understanding
4
compared achieved
4
remission compared
4
role immune
4
complete remission
4
months cases
4

Similar Publications