Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.

Authors:
James R Cerhan Sonja I Berndt Joseph Vijai Hervé Ghesquières James McKay Sophia S Wang Zhaoming Wang Meredith Yeager Lucia Conde Paul I W de Bakker Alexandra Nieters David Cox Laurie Burdett Alain Monnereau Christopher R Flowers Anneclaire J De Roos Angela R Brooks-Wilson Qing Lan Gianluca Severi Mads Melbye Jian Gu Rebecca D Jackson Eleanor Kane Lauren R Teras Mark P Purdue Claire M Vajdic John J Spinelli Graham G Giles Demetrius Albanes Rachel S Kelly Mariagrazia Zucca Kimberly A Bertrand Anne Zeleniuch-Jacquotte Charles Lawrence Amy Hutchinson Degui Zhi Thomas M Habermann Brian K Link Anne J Novak Ahmet Dogan Yan W Asmann Mark Liebow Carrie A Thompson Stephen M Ansell Thomas E Witzig George J Weiner Amelie S Veron Diana Zelenika Hervé Tilly Corinne Haioun Thierry Jo Molina Henrik Hjalgrim Bengt Glimelius Hans-Olov Adami Paige M Bracci Jacques Riby Martyn T Smith Elizabeth A Holly Wendy Cozen Patricia Hartge Lindsay M Morton Richard K Severson Lesley F Tinker Kari E North Nikolaus Becker Yolanda Benavente Paolo Boffetta Paul Brennan Lenka Foretova Marc Maynadie Anthony Staines Tracy Lightfoot Simon Crouch Alex Smith Eve Roman W Ryan Diver Kenneth Offit Andrew Zelenetz Robert J Klein Danylo J Villano Tongzhang Zheng Yawei Zhang Theodore R Holford Anne Kricker Jenny Turner Melissa C Southey Jacqueline Clavel Jarmo Virtamo Stephanie Weinstein Elio Riboli Paolo Vineis Rudolph Kaaks Dimitrios Trichopoulos Roel C H Vermeulen Heiner Boeing Anne Tjonneland Emanuele Angelucci Simonetta Di Lollo Marco Rais Brenda M Birmann Francine Laden Edward Giovannucci Peter Kraft Jinyan Huang Baoshan Ma Yuanqing Ye Brian C H Chiu Joshua Sampson Liming Liang Ju-Hyun Park Charles C Chung Dennis D Weisenburger Nilanjan Chatterjee Joseph F Fraumeni Susan L Slager Xifeng Wu Silvia de Sanjose Karin E Smedby Gilles Salles Christine F Skibola Nathaniel Rothman Stephen J Chanock

Nat Genet 2014 Nov 28;46(11):1233-8. Epub 2014 Sep 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

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http://dx.doi.org/10.1038/ng.3105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213349PMC
November 2014
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References

(Supplied by CrossRef)
Article in CA Cancer J. Clin.
R Siegel et al.
CA Cancer J. Clin. 2013
Article in CA Cancer J. Clin.
CR Flowers et al.
CA Cancer J. Clin. 2010
Article in Blood
SS Wang et al.
Blood 2007
Article in Br. J. Haematol.
LR Goldin et al.
Br. J. Haematol. 2009
Article in Am. J. Epidemiol.
CF Skibola et al.
Am. J. Epidemiol. 2010
Article in Nat. Genet.
CF Skibola et al.
Nat. Genet. 2009
Article in Nat. Genet.
L Conde et al.
Nat. Genet. 2010
Article in PLoS Genet.
KE Smedby et al.
PLoS Genet. 2011
Article in PLoS Genet.
J Vijai et al.
PLoS Genet. 2013
Article in Nat. Genet.
DE Tan et al.
Nat. Genet. 2013
Article in Nat. Genet.
Z Wang et al.
Nat. Genet. 2012

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