Predictive factors associated with gefitinib response in patients with advanced non-small-cell lung cancer (NSCLC).

Chin J Cancer Res 2014 Aug;26(4):466-70

1 Southern Medical University, Guangzhou 510515, China ; 2 Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China ; 3 Department of Respiratory Diseases, SUN Yat-sen Memorial Hospital, SUN Yat-sen University, Guangzhou 510120, China ; 4 Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

Purpose: A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in advanced non-small-cell lung cancer (NSCLC). This study aimed to identify predictive factors associated with prognostic benefits of gefitinib.

Patients And Methods: EGFR gene typing in 33 advanced NSCLC patients received gefitinib (250 mg/day) were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively.

Results: The overall objective response rate (ORR) and median progression-free survival (PFS) in the 33 patients treated by gefitinib were 45.5% and 3.0 (2.0-4.0) months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients (P<0.01). Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients (P<0.05, P<0.01, respectively). However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR (P<0.01). Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS (P<0.05).

Conclusions: EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients.

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Source
http://www.cjcrcn.org/article/html_4351.html
Publisher Site
http://dx.doi.org/10.3978/j.issn.1000-9604.2014.08.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153923PMC
August 2014
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