Search our Database of Scientific Publications and Authors

I’m looking for a
    Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults.
    PLoS One 2014 17;9(9):e107413. Epub 2014 Sep 17.
    The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America.
    Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.

    Similar Publications

    Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80.
    Behav Brain Res 2015 May 2;284:51-7. Epub 2015 Feb 2.
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA.
    The neuroprotective effects of physical activity (PA) are consistently shown in older adults, but the neural substrates, particularly in white matter (WM), are understudied, especially in very old adults with the fastest growth rate and the highest risk of dementia. This study quantified the association between PA and WM integrity in adults over 80. The moderating effects of cardiometabolic conditions, physical functional limitations and WM hyperintensities were also examined, as they can affect PA and brain integrity. Read More
    Physical Activity Is Linked to Greater Moment-To-Moment Variability in Spontaneous Brain Activity in Older Adults.
    PLoS One 2015 5;10(8):e0134819. Epub 2015 Aug 5.
    The Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana, IL, United States of America.
    Higher cardiorespiratory fitness (CRF) and physical activity (PA) in old age are associated with greater brain structural and functional integrity, and higher cognitive functioning. However, it is not known how different aspects of lifestyle such as sedentariness, light PA (LI-PA), or moderate-to-vigorous physical activity (MV-PA) relate to neural activity in aging. In addition, it is not known whether the effects of PA on brain function differ or overlap with those of CRF. Read More
    White matter integrity, hippocampal volume, and cognitive performance of a world-famous nonagenarian track-and-field athlete.
    Neurocase 2016 3;22(2):135-44. Epub 2015 Aug 3.
    a The Beckman Institute for Advanced Science and Technology at the University of Illinois , Urbana , IL 61801 , USA.
    Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with successful brain and cognitive aging. However, little is known about the effects of PA, CRF, and exercise on the brain in the oldest-old. Here we examined white matter (WM) integrity, measured as fractional anisotropy (FA) and WM hyperintensity (WMH) burden, and hippocampal (HIPP) volume of Olga Kotelko (1919-2014). Read More
    The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention.
    Hum Brain Mapp 2013 Nov 5;34(11):2972-85. Epub 2012 Jun 5.
    Department of Psychology, The University of Iowa, Iowa.
    Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one-year exercise intervention. Read More