New cytotoxic sesquiterpene lactones from Anthemis scrobicularis.

J Asian Nat Prod Res 2014 17;16(9):922-9. Epub 2014 Sep 17.

a Pharmacognosy Department , College of Pharmacy, Salman Bin Abdulaziz University , Al-Kharj 11942 , Kingdom of Saudi Arabia.

Four new sesquiterpene lactones, 4α-hydroxy-guaia-10(14),11(13)-diene-12,6α-olide (1), 4α-hydroxy-9α-acetoxy-guaia-1(10),2-diene-12,6α-olide (4), 4α-hydroxy-9β-acetoxy-guaia-1(10),2-diene-12,6α-olide (5), and 1α,4α-dihydroxy-9α-acetoxy-guaia-10(14),2-diene-12,6α-olide (6), were isolated from the aerial parts of Anthemis scrobicularis. Their structures were elucidated on the basis of their IR, NMR, and MS spectroscopic data. In addition, two known sesquiterpene lactones micheliolide (2) and achillin (3) were also isolated. The cytotoxicity of some of the isolated compounds was tested against HCT 116, HepG-2, and MCF-7 cell lines. Micheliolide and 4α-hydroxy-guaia-10(14),11(13)-diene-12,6α-olide showed pronounced inhibitory activity while 4α-hydroxy-9α-acetoxy-guaia-1(10),2-diene-12,6α-olide showed weak activity.

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.1080/10286020.2014.931
Publisher Site
http://dx.doi.org/10.1080/10286020.2014.931377DOI Listing
November 2014

Publication Analysis

Top Keywords

sesquiterpene lactones
12
anthemis scrobicularis
8
spectroscopic data
4
micheliolide 4α-hydroxy-guaia-10141113-diene-126α-olide
4
data addition
4
addition sesquiterpene
4
nmr spectroscopic
4
lactones micheliolide
4
4α-hydroxy-guaia-10141113-diene-126α-olide pronounced
4
116 hepg-2
4
pronounced inhibitory
4
elucidated basis
4
basis nmr
4
lines micheliolide
4
achillin isolated
4
compounds tested
4
tested hct
4
hepg-2 mcf-7
4
hct 116
4
mcf-7 cell
4

Similar Publications