Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients.

Br J Haematol 2014 Dec 11;167(5):692-6. Epub 2014 Sep 11.

Department of Haematology, University College London, London, UK.

In transfusional iron overload, extra-hepatic iron distribution differs, depending on the underlying condition. Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences. Markers of iron metabolism (plasma NTBI, labile iron, hepcidin, transferrin, monocyte SLC40A1 [ferroportin]), erythropoiesis (growth differentiation factor 15, soluble transferrin receptor) and tissue hypoxia (erythropoietin) were compared in patients with Thalassaemia Major (TM), Sickle Cell Disease and Diamond-Blackfan Anaemia (DBA), with matched transfusion histories. The most striking differences between these conditions were relationships of NTBI to erythropoietic markers, leading us to propose three mechanisms of NTBI generation: iron overload (all), ineffective erythropoiesis (predominantly TM) and low transferrin-iron utilization (DBA).

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http://dx.doi.org/10.1111/bjh.13081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577015PMC
December 2014
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References

(Supplied by CrossRef)
Consequences and management of iron overload in sickle cell disease
Porter et al.
Hematology/the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2013

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