Enhanced two-photon fluorescence imaging and therapy of cancer cells via Gold@bridged silsesquioxane nanoparticles.

Authors:
Jonas Croissant
Jonas Croissant
Smart Hybrid Materials Laboratory
United States
Marie Maynadier
Marie Maynadier
NanoMedSyn
Montpellier | France
Olivier Mongin
Olivier Mongin
Université de Rennes 1
Rennes | France
Vincent Hugues
Vincent Hugues
Institute of Molecular Sciences (CNRS UMR 5255)
France
Arnaud Chaix
Arnaud Chaix
Institut Charles Gerhardt Montpellier

Small 2015 Jan 10;11(3):295-9. Epub 2014 Sep 10.

Institut Charles Gerhardt Montpellier, UMR-5253, CNRS-UM2-ENSCM-UM1, cc 1701, Place Eugène Bataillon, F-34095, Montpellier cedex 05, France.

A two-photon photosensitizer with four triethoxysilyl groups is synthesized through the click reaction. This photosensitizer allows the design of bridged silsesquioxane (BS) nanoparticles through a sol-gel process; moreover, gold core BS shells or BS nanoparticles decorated with gold nanospheres are synthesized. An enhancement of the two-photon properties is noted with gold and the nanoparticles are efficient for two-photon imaging and two-photon photodynamic therapy of cancer cells.

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January 2015
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