J Neurol Sci 2014 Nov 23;346(1-2):194-6. Epub 2014 Aug 23.
MS Centre, SCDU Neurology, Head and Neck Department, AOU "Maggiore della Carità", Corso Mazzini 18, 28100 Novara, Italy; Interdisciplinary Research Center of Autoimmune Diseases IRCAD, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy. Electronic address:
Background: Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.
Objectives: To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.
Methods: Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.
Results: No significant temporal trend was found after adjustment for multiple comparisons.
Conclusions: Birth timing showed no association with MS progression in Italian patients.