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J Gen Physiol 2021 May;153(5)

Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.

Inwardly rectifying potassium (Kir) channels are broadly expressed in both excitable and nonexcitable tissues, where they contribute to a wide variety of cellular functions. Numerous studies have established that rectification of Kir channels is not an inherent property of the channel protein itself, but rather reflects strong voltage dependence of channel block by intracellular cations, such as polyamines and Mg2+. Here, we identify a previously unknown mechanism of inward rectification in Kir4. Read More

Bioresour Technol 2021 Mar 15;323:124542. Epub 2020 Dec 15.

Bielefeld University, Faculty of Biology, Center for Biotechnology (CeBiTec), Universitätsstrasse 27, 33615 Bielefeld, Germany. Electronic address:

Modern chemical industry calls for new resource-efficient and sustainable value chains for production of key base chemicals such as polyamines. The green microalga Chlamydomonas reinhardtii offers great potential as an innovative green-cell factory by combining fast and inexpensive, phototrophic growth with mature genetic engineering. Here, overexpression of recombinant lysine decarboxylases in C. Read More

Cells 2020 11 10;9(11). Epub 2020 Nov 10.

Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, Korea.

Fatty acid synthase (FAS) is a key enzyme involved in de novo lipogenesis that produces lipids that are necessary for cell growth and signal transduction, and it is known to be overexpressed, especially in cancer cells. Although lipid metabolism alteration is an important metabolic phenotype in cancer cells, the development of drugs targeting FAS to block lipid synthesis is hampered by the characteristics of cancer cells with metabolic flexibility leading to rapid adaptation and resistance. Therefore, to confirm the metabolic alterations at the cellular level during FAS inhibition, we treated LNCaP-LN3 prostate cancer cells with FAS inhibitors (Fasnall, GSK2194069, and TVB-3166). Read More

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Jul;36(4):330-335

Medical College of China Three Gorges University, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443002, China.

Objective: To investigate the effects of a novel polyamine metabolism enzyme inhibitor SI-4650 on autophagy and apoptosis of colon cancer CT-26 cells as well as their correlation.

Methods: CT-26 cells treated with 40, 80 μmol·L SI-4650 alone or in combination with 3-MA were used as experimental group. CT-26 cells treated with 0 μmol·L SI-4650 alone or in combination with 3-MA were used as control group. Read More

Acta Parasitol 2020 Nov 6. Epub 2020 Nov 6.

Laboratory of Venom and Biotherapeutics Molecules, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Purpose: The aim of this study was to explore the activity of Naja naja oxiana venom on Leishmania tropica and its modes of action.

Methods: Different fractions of Naja naja oxiana venom (NNOV) were prepared and characterized by high-performance liquid chromatography. The superior component, fraction k (FK) was selected. Read More