Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy
Maddalena Illario
Maddalena Illario
University of Naples Federico II
Napoli | Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Transl Med UniSa 2014 Sep 8;10:3-7. Epub 2014 Apr 8.

Department of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy; ; IRCCS Multimedica, Milano, Italy.

G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner. In this review we have dealt with the recently discovered roles of GRK2 in the regulation of cell metabolism. In particular, we have focused on recent findings about the mitochondrial role of GRK2 in the regulation of energy metabolism. Few findings exist about this topic that all concur to identify a mitochondrial localization of GRK2, leading to the rising of the following question: is GRK2 detrimental or advantageous for mitochondrial function? By the review of available literature, a new concept arises about GRK2 role into the cell,which is that of a stress protein acutely activated by cellular stress whose specific subcellular localization, in particular mitochondrial localization, results in compensatory metabolic responses. Thus, the possibility to regulate GRK2 trafficking within the cell is a promising strategy to regulate the adaptative effects of the kinase on cell metabolism.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140422PMC
September 2014
9 Reads
7 Citations

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