Obesity, physical activity, and their interaction in incident atrial fibrillation in postmenopausal women.

J Am Heart Assoc 2014 Aug 20;3(4). Epub 2014 Aug 20.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA (F.A., T.L.A., M.A.H., M.V.P.).

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased risk of stroke and death. Obesity is an independent risk factor for AF, but modifiers of this risk are not well known. We studied the roles of obesity, physical activity, and their interaction in conferring risk of incident AF.

Methods And Results: The Women's Health Initiative (WHI) Observational Study was a prospective observational study of 93 676 postmenopausal women followed for an average of 11.5 years. Incident AF was identified using WHI-ascertained hospitalization records and diagnostic codes from Medicare claims. A multivariate Cox's hazard regression model adjusted for demographic and clinical risk factors was used to evaluate the interaction between obesity and physical activity and its association with incident AF. After exclusion of women with prevalent AF, incomplete data, or underweight body mass index (BMI), 9792 of the remaining 81 317 women developed AF. Women were, on average, 63.4 years old, 7.8% were African American, and 3.6% were Hispanic. Increased BMI (hazard ratio [HR], 1.12 per 5-kg/m(2) increase; 95% confidence interval [CI], 1.10 to 1.14) and reduced physical activity (>9 vs. 0 metabolic equivalent task hours per week; HR, 0.90; 95% CI, 0.85 to 0.96) were independently associated with higher rates of AF after multivariate adjustment. Higher levels of physical activity reduced the AF risk conferred by obesity (interaction P=0.033).

Conclusions: Greater physical activity is associated with lower rates of incident AF and modifies the association between obesity and incident AF.

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.114.001127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310412PMC
August 2014
28 Reads

Publication Analysis

Top Keywords

physical activity
24
obesity physical
12
activity interaction
8
postmenopausal women
8
observational study
8
atrial fibrillation
8
women average
8
risk
6
obesity
6
activity
6
incident
6
physical
5
women
5
114 reduced
4
[ci] 110
4
cox's hazard
4
claims multivariate
4
hazard regression
4
110 114
4
multivariate cox's
4

References

(Supplied by CrossRef)

Similar Publications