Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Nat Rev Drug Discov 2014 Sep 18;13(9):673-91. Epub 2014 Aug 18.

1] Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne 3002, Victoria, Australia. [2] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3052, Victoria, Australia.

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are often caused by genetic defects that result in functional deregulation of epigenetic proteins, their altered expression and/or their atypical recruitment to certain gene promoters. Importantly, epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules. This Review discusses the role of altered expression and/or function of one class of epigenetic regulators--histone deacetylases (HDACs)--and their role in cancer, neurological diseases and immune disorders. We highlight the development of small-molecule HDAC inhibitors and their use in the laboratory, in preclinical models and in the clinic.

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Source
http://www.nature.com/articles/nrd4360
Publisher Site
http://dx.doi.org/10.1038/nrd4360DOI Listing
September 2014
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